TY  - JOUR
AU  - ICGC/TCGAPan-CancerAnalysisofWholeGenomesConsortium
TI  - Pan-cancer analysis of whole genomes.
JO  - Nature 
VL  - 578
IS  - 7793
SN  - 1476-4687
CY  - London [u.a.]
PB  - Nature Publ. Group52462
M1  - DKFZ-2020-01051
SP  - 82 - 93
PY  - 2020
N1  - 2020 Feb;578(7793):82-93 / siehe Correction: DKFZ Autoren affiliiert im PCAWG Consortium: https://inrepo02.dkfz.de/record/265692   /  https://doi.org/10.1038/s41586-022-05598-w
AB  - Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1-3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5
KW  - Cell Proliferation: genetics
KW  - Cellular Senescence: genetics
KW  - Chromothripsis
KW  - Cloud Computing
KW  - DNA Mutational Analysis
KW  - Evolution, Molecular
KW  - Female
KW  - Genome, Human: genetics
KW  - Genomics
KW  - Germ-Line Mutation: genetics
KW  - High-Throughput Nucleotide Sequencing
KW  - Humans
KW  - Information Dissemination
KW  - Male
KW  - Mutagenesis: genetics
KW  - Mutation
KW  - Neoplasms: classification
KW  - Neoplasms: genetics
KW  - Neoplasms: pathology
KW  - Oncogenes: genetics
KW  - Promoter Regions, Genetic: genetics
KW  - RNA Splicing: genetics
KW  - Reproducibility of Results
KW  - Telomerase: genetics
KW  - Telomere: genetics
KW  - TERT protein, human (NLM Chemicals)
KW  - Telomerase (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:32025007
C2  - pmc:PMC7025898
DO  - DOI:10.1038/s41586-020-1969-6
UR  - https://inrepo02.dkfz.de/record/156705
ER  -