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@ARTICLE{Ellison:156718,
      author       = {D. W. Ellison and K. D. Aldape and D. Capper$^*$ and M.
                      Fouladi and M. R. Gilbert and R. J. Gilbertson and C.
                      Hawkins and T. Merchant and K. Pajtler$^*$ and S. Venneti
                      and D. N. Louis},
      title        = {c{IMPACT}-{NOW} update 7: advancing the molecular
                      classification of ependymal tumors.},
      journal      = {Brain pathology},
      volume       = {30},
      number       = {5},
      issn         = {1750-3639},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2020-01056},
      pages        = {863-866},
      year         = {2020},
      note         = {2020 Sep;30(5):863-866},
      abstract     = {Advances in our understanding of the biological basis and
                      molecular characteristics of ependymal tumors since the
                      latest iteration of the World Health Organization (WHO)
                      classification of CNS tumors (2016) have prompted the
                      cIMPACT-NOW group to recommend a new classification.
                      Separation of ependymal tumors by anatomic site is an
                      important principle of the new classification and was
                      prompted by methylome profiling data to indicate that
                      molecular groups of ependymal tumors in the posterior fossa
                      and supratentorial and spinal compartments are distinct.
                      Common recurrent genetic or epigenetic alterations found in
                      tumors belonging to the main molecular groups have been used
                      to define tumor types at intracranial sites; C11orf95 and
                      YAP1 fusion genes for supratentorial tumors and two types of
                      posterior fossa ependymoma defined by methylation group, PFA
                      and PFB. A recently described type of aggressive spinal
                      ependymoma with MYCN amplification has also been included.
                      Myxopapillary ependymoma and subependymoma have been
                      retained as histopathologically defined tumor types, but the
                      classification has dropped the distinction between classic
                      and anaplastic ependymoma. While the cIMPACT-NOW group
                      considered that data to inform assignment of grade to
                      molecularly defined ependymomas are insufficiently mature,
                      it recommends assigning WHO grade 2 to myxopapillary
                      ependymoma and allows grade 2 or grade 3 to be assigned to
                      ependymomas not defined by molecular status.},
      subtyp        = {Review Article},
      cin          = {HD01 / B062},
      ddc          = {610},
      cid          = {I:(DE-He78)HD01-20160331 / I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32502305},
      doi          = {10.1111/bpa.12866},
      url          = {https://inrepo02.dkfz.de/record/156718},
}