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@ARTICLE{Guberina:156721,
      author       = {M. Guberina and A. Sak and C. Pöttgen and I.
                      Tinhofer-Keilholz$^*$ and V. Budach$^*$ and P. Balermpas and
                      J. Von der Grün$^*$ and C. M. Rödel$^*$ and E. Gikka and
                      A.-L. Grosu$^*$ and A. Abdollahi$^*$ and J. Debus$^*$ and C.
                      Belka$^*$ and S. Pigorsch$^*$ and S. Combs$^*$ and D.
                      Mönnich$^*$ and D. Zips$^*$ and C. De-Colle and S. Welz and
                      A. Linge$^*$ and F. Lohaus$^*$ and G. Baretton$^*$ and T.
                      Gauler and M. Baumann$^*$ and M. Krause$^*$ and M.
                      Schuler$^*$ and A. Bankfalvi and B. Höing and S. Lang and
                      M. Stuschke},
      title        = {{ERCC}2 gene single-nucleotide polymorphism as a prognostic
                      factor for locally advanced head and neck carcinomas after
                      definitive cisplatin-based radiochemotherapy.},
      journal      = {The pharmacogenomics journal},
      volume       = {21},
      number       = {1},
      issn         = {1473-1150},
      address      = {Basingstoke},
      publisher    = {Nature Publishing Group},
      reportid     = {DKFZ-2020-01059},
      pages        = {37-46},
      year         = {2021},
      note         = {2021 Feb;21(1):37-46},
      abstract     = {Identifying patients with locally advanced head and neck
                      carcinoma on high risk of recurrence after definitive
                      concurrent radiochemotherapy is of key importance for the
                      selection for consolidation therapy and for individualized
                      treatment intensification. In this multicenter study we
                      analyzed recurrence-associated single-nucleotide
                      polymorphisms (SNPs) in DNA repair genes in tumor DNA from
                      132 patients with locally advanced head and neck carcinoma
                      (LadHnSCC). Patients were treated with definitive
                      radiotherapy and simultaneous cisplatin-based chemotherapy
                      at six partner sites of the German Cancer Consortium (DKTK)
                      Radiation Oncology Group from 2005 to 2011. For validation,
                      a group of 20 patients was available. Score selection method
                      using proportional hazard analysis and leave-one-out
                      cross-validation were performed to identify markers
                      associated with outcome. The SNPs rs1799793 and rs13181 were
                      associated with survival and the same SNPs and in addition
                      rs17655 with freedom from loco-regional relapse (ffLRR) in
                      the trainings datasets from all patients. The homozygote
                      major rs1799793 genotype at the ERCC2 gene was associated
                      with better (Hazard ratio (HR): 0.418 (0.234-0.744),
                      p = 0.003) and the homozygote minor rs13181 genotype at
                      ERCC2 with worse survival (HR: 2.074, $95\%$ CI
                      (1.177-3.658), p = 0.017) in comparison to the other
                      genotypes. At the ffLRR endpoint, rs1799793 and rs13181 had
                      comparable prognostic value. The rs1799793 and rs13181
                      genotypes passed the leave-one-out cross-validation
                      procedure and associated with survival and ffLRR in patients
                      with LadHnSCC treated with definitive radiochemotherapy.
                      While findings were confirmed in a small validation dataset,
                      further validation is underway within a prospective
                      biomarker study of the DKTK.},
      cin          = {BE01 / FR01 / HD01 / FM01 / E210 / E050 / M010 / DD01 /
                      MU01 / TU01 / ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331 / I:(DE-He78)FR01-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)FM01-20160331 /
                      I:(DE-He78)E210-20160331 / I:(DE-He78)E050-20160331 /
                      I:(DE-He78)M010-20160331 / I:(DE-He78)DD01-20160331 /
                      I:(DE-He78)MU01-20160331 / I:(DE-He78)TU01-20160331 /
                      I:(DE-He78)ED01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32546699},
      doi          = {10.1038/s41397-020-0174-1},
      url          = {https://inrepo02.dkfz.de/record/156721},
}