000156724 001__ 156724
000156724 005__ 20240229133504.0
000156724 0247_ $$2doi$$a10.1038/s41380-020-0764-y
000156724 0247_ $$2pmid$$apmid:32404947
000156724 0247_ $$2ISSN$$a1359-4184
000156724 0247_ $$2ISSN$$a1476-5578
000156724 0247_ $$2altmetric$$aaltmetric:82085869
000156724 037__ $$aDKFZ-2020-01062
000156724 041__ $$aeng
000156724 082__ $$a610
000156724 1001_ $$0P:(DE-He78)f0a01df447f74d4e57b596d985130a15$$aStöcker, Sarah$$b0$$eFirst author
000156724 245__ $$aPrediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years.
000156724 260__ $$aLondon$$bMacmillan$$c2021
000156724 3367_ $$2DRIVER$$aarticle
000156724 3367_ $$2DataCite$$aOutput Types/Journal article
000156724 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1685452003_28112
000156724 3367_ $$2BibTeX$$aARTICLE
000156724 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000156724 3367_ $$00$$2EndNote$$aJournal Article
000156724 500__ $$a26, pages 5812–5822 (2021) / #EA:C070#LA:C070#
000156724 520__ $$aThe strongest genetic risk factor for Alzheimer's disease (AD) is the ε4 allele of Apolipoprotein E (APOE) and recent genome-wide association meta-analyses have confirmed additional associated genetic loci with smaller effects. The aim of this study was to investigate the ability of an AD polygenic risk score (PRS) and APOE status to predict clinical diagnosis of AD, vascular (VD), mixed (MD), and all-cause dementia in a community-based cohort prospectively followed over 17 years and secondarily across age, sex, and education strata. A PRS encompassing genetic variants reaching genome-wide significant associations to AD (excluding APOE) from the most recent genome-wide association meta-analysis data was calculated and APOE status was determined in 5203 participants. During follow-up, 103, 111, 58, and 359 participants were diagnosed with AD, VD, MD, and all-cause dementia, respectively. Prediction ability of AD, VD, MD, and all-cause dementia by the PRS and APOE was assessed by multiple logistic regression and receiver operating characteristic curve analyses. The PRS per standard deviation increase in score and APOE4 positivity (≥1 ε4 allele) were significantly associated with greater odds of AD (OR, 95% CI: PRS: 1.70, 1.45-1.99; APOE4: 3.34, 2.24-4.99) and AD prediction accuracy was significantly improved when adding the PRS to a base model of age, sex, and education (ASE) (c-statistics: ASE, 0.772; ASE + PRS, 0.810). The PRS enriched the ability of APOE to discern AD with stronger associations than to VD, MD, or all-cause dementia in a prospective community-based cohort.
000156724 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000156724 588__ $$aDataset connected to CrossRef, PubMed,
000156724 7001_ $$0P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aPerna, Laura$$b1$$udkfz
000156724 7001_ $$0P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aWeigl, K.$$b2$$udkfz
000156724 7001_ $$0P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aMöllers, T.$$b3$$udkfz
000156724 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, B.$$b4$$udkfz
000156724 7001_ $$aThomsen, H.$$b5
000156724 7001_ $$aHolleczek, B.$$b6
000156724 7001_ $$aRujescu, D.$$b7
000156724 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b8$$eLast author$$udkfz
000156724 773__ $$0PERI:(DE-600)1502531-7$$a10.1038/s41380-020-0764-y$$p5812–5822$$tMolecular psychiatry$$v26$$x1476-5578$$y2021
000156724 909CO $$ooai:inrepo02.dkfz.de:156724$$pVDB
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f0a01df447f74d4e57b596d985130a15$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d9d72431035d8535d1b65ce9a01c2f60$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6cc3cc35505b446fde081e7cd89a4b87$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000156724 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000156724 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000156724 9141_ $$y2021
000156724 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMOL PSYCHIATR : 2018$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-01-09
000156724 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bMOL PSYCHIATR : 2018$$d2020-01-09
000156724 9202_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000156724 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000156724 9200_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000156724 980__ $$ajournal
000156724 980__ $$aVDB
000156724 980__ $$aI:(DE-He78)C070-20160331
000156724 980__ $$aUNRESTRICTED