TY  - JOUR
AU  - Rühle, Alexander
AU  - Haehl, Erik
AU  - David, Hélène
AU  - Kalckreuth, Tobias
AU  - Sprave, Tanja
AU  - Stoian, Raluca
AU  - Zamboglou, Constantinos
AU  - Gkika, Eleni
AU  - Knopf, Andreas
AU  - Grosu, Anca-Ligia
AU  - Nicolay, Nils
TI  - The Value of Laboratory Parameters for Anemia, Renal Function, Systemic Inflammation and Nutritional Status as Predictors for Outcome in Elderly Patients with Head-and-Neck Cancers.
JO  - Cancers
VL  - 12
IS  - 6
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-01090
SP  - E1698
PY  - 2020
N1  - #EA:E055#LA:E055#
AB  - The purpose of this study was to evaluate the value of routine blood markers regarding their predictive potential for treatment outcomes of elderly head-and-neck squamous cell carcinoma (HNSCC) patients. In total, 246 elderly HNSCC patients (≥65 years) undergoing (chemo)radiotherapy from 2010 to 2018 were analyzed for treatment outcomes, depending on their hemoglobin, glomerular filtration rate (GFR), C-reactive protein (CRP) and albumin values, representing anemia, kidney function, inflammation and nutrition status, respectively. Local/locoregional control, progression-free and overall survival (OS) were calculated using the Kaplan-Meier method. Cox analyses were performed to examine the influence of blood parameters on oncological outcomes. In the univariate Cox regression analysis, hemoglobin ≤ 12 g/dL (HR = 1.536, p < 0.05), a GFR ≤ 60 mL/min/1.73 m2 (HR = 1.537, p < 0.05), a CRP concentration > 5 mg/L (HR = 1.991, p < 0.001) and albumin levels ≤ 4.2 g/dL (HR = 2.916, p < 0.001) were significant risk factors for OS. In the multivariate analysis including clinical risk factors, only performance status (HR = 2.460, p < 0.05) and baseline albumin (HR = 2.305, p < 0.05) remained significant prognosticators. Additionally, baseline anemia correlated with the prevalence of higher-grade chronic toxicities. We could show for the first time that laboratory parameters for anemia (and at least partly, tumor oxygenation), decreased renal function, inflammation and reduced nutrition status are associated with impaired survival in elderly HNSCC patients undergoing (chemo)radiotherapy.
LB  - PUB:(DE-HGF)16
C6  - pmid:32604773
DO  - DOI:10.3390/cancers12061698
UR  - https://inrepo02.dkfz.de/record/156766
ER  -