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@ARTICLE{Rhle:156766,
      author       = {A. Rühle$^*$ and E. Haehl$^*$ and H. David$^*$ and T.
                      Kalckreuth$^*$ and T. Sprave$^*$ and R. Stoian$^*$ and C.
                      Zamboglou$^*$ and E. Gkika$^*$ and A. Knopf and A.-L.
                      Grosu$^*$ and N. Nicolay$^*$},
      title        = {{T}he {V}alue of {L}aboratory {P}arameters for {A}nemia,
                      {R}enal {F}unction, {S}ystemic {I}nflammation and
                      {N}utritional {S}tatus as {P}redictors for {O}utcome in
                      {E}lderly {P}atients with {H}ead-and-{N}eck {C}ancers.},
      journal      = {Cancers},
      volume       = {12},
      number       = {6},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-01090},
      pages        = {E1698},
      year         = {2020},
      note         = {#EA:E055#LA:E055#},
      abstract     = {The purpose of this study was to evaluate the value of
                      routine blood markers regarding their predictive potential
                      for treatment outcomes of elderly head-and-neck squamous
                      cell carcinoma (HNSCC) patients. In total, 246 elderly HNSCC
                      patients (≥65 years) undergoing (chemo)radiotherapy from
                      2010 to 2018 were analyzed for treatment outcomes, depending
                      on their hemoglobin, glomerular filtration rate (GFR),
                      C-reactive protein (CRP) and albumin values, representing
                      anemia, kidney function, inflammation and nutrition status,
                      respectively. Local/locoregional control, progression-free
                      and overall survival (OS) were calculated using the
                      Kaplan-Meier method. Cox analyses were performed to examine
                      the influence of blood parameters on oncological outcomes.
                      In the univariate Cox regression analysis, hemoglobin ≤ 12
                      g/dL (HR = 1.536, p < 0.05), a GFR ≤ 60 mL/min/1.73 m2 (HR
                      = 1.537, p < 0.05), a CRP concentration > 5 mg/L (HR =
                      1.991, p < 0.001) and albumin levels ≤ 4.2 g/dL (HR =
                      2.916, p < 0.001) were significant risk factors for OS. In
                      the multivariate analysis including clinical risk factors,
                      only performance status (HR = 2.460, p < 0.05) and baseline
                      albumin (HR = 2.305, p < 0.05) remained significant
                      prognosticators. Additionally, baseline anemia correlated
                      with the prevalence of higher-grade chronic toxicities. We
                      could show for the first time that laboratory parameters for
                      anemia (and at least partly, tumor oxygenation), decreased
                      renal function, inflammation and reduced nutrition status
                      are associated with impaired survival in elderly HNSCC
                      patients undergoing (chemo)radiotherapy.},
      cin          = {E055 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32604773},
      doi          = {10.3390/cancers12061698},
      url          = {https://inrepo02.dkfz.de/record/156766},
}