%0 Journal Article
%A Galeotti, Alice Alessandra
%A Gentiluomo, Manuel
%A Rizzato, Cosmeri
%A Obazee, Ofure Mary Ann
%A Neoptolemos, John P
%A Pasquali, Claudio
%A Nentwich, Michael
%A Cavestro, Giulia Martina
%A Pezzilli, Raffaele
%A Greenhalf, William
%A Holleczek, Bernd
%A Schroeder, Cornelia
%A Schöttker, Ben
%A Ivanauskas, Audrius
%A Ginocchi, Laura
%A Key, Timothy J
%A Hegyi, Péter
%A Archibugi, Livia
%A Darvasi, Erika
%A Basso, Daniela
%A Sperti, Cosimo
%A Bijlsma, Maarten F
%A Palmieri, Orazio
%A Hlavac, Viktor
%A Talar-Wojnarowska, Renata
%A Mohelnikova-Duchonova, Beatrice
%A Hackert, Thilo
%A Vashist, Yogesh
%A Strouhal, Ondrej
%A van Laarhoven, Hanneke
%A Tavano, Francesca
%A Lovecek, Martin
%A Dervenis, Christos
%A Izbéki, Ferenc
%A Padoan, Andrea
%A Małecka-Panas, Ewa
%A Maiello, Evaristo
%A Vanella, Giuseppe
%A Capurso, Gabriele
%A Izbicki, Jakob R
%A Theodoropoulos, George E
%A Jamroziak, Krzysztof
%A Katzke, Verena
%A Kaaks, Rudolf
%A Mambrini, Andrea
%A Papanikolaou, Ioannis S
%A Szmola, Richárd
%A Szentesi, Andrea
%A Kupcinskas, Juozas
%A Bursi, Simona
%A Costello, Eithne
%A Boggi, Ugo
%A Milanetto, Anna Caterina
%A Landi, Stefano
%A Gazouli, Maria
%A Vodickova, Ludmila
%A Soucek, Pavel
%A Gioffreda, Domenica
%A Gemignani, Federica
%A Brenner, Hermann
%A Strobel, Oliver
%A Büchler, Markus
%A Vodicka, Pavel
%A Paiella, Salvatore
%A Canzian, Federico
%A Campa, Daniele
%T Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.
%J Journal of medical genetics
%V 58
%N 6
%@ 1468-6244
%C London
%I BMJ Publishing Group
%M DKFZ-2020-01093
%P 369-377
%D 2021
%Z 2021 Jun;58(6):369-377#EA:C055#
%X Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection.We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of known risk SNPs, and carried out an exploratory analysis of a multifactorial score.We tested the associations of the individual known risk SNPs on up to 2851 PDAC cases and 4810 controls of European origin from the PANcreatic Disease ReseArch (PANDoRA) consortium. Thirty risk SNPs were included in a PRS, which was computed on the subset of subjects that had 100
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32591343
%R 10.1136/jmedgenet-2020-106961
%U https://inrepo02.dkfz.de/record/156769