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000156769 1001_ $$0P:(DE-He78)968599a64363d6e5be39515f3ef8a598$$aGaleotti, Alice Alessandra$$b0$$eFirst author
000156769 245__ $$aPolygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.
000156769 260__ $$aLondon$$bBMJ Publishing Group$$c2021
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000156769 520__ $$aMost cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing PDAC would be useful to improve chances of early detection.We generated a polygenic risk score (PRS) for PDAC risk prediction, combining the effect of known risk SNPs, and carried out an exploratory analysis of a multifactorial score.We tested the associations of the individual known risk SNPs on up to 2851 PDAC cases and 4810 controls of European origin from the PANcreatic Disease ReseArch (PANDoRA) consortium. Thirty risk SNPs were included in a PRS, which was computed on the subset of subjects that had 100% call rate, consisting of 839 cases and 2040 controls in PANDoRA and 6420 cases and 4889 controls from the previously published Pancreatic Cancer Cohort Consortium I-III and Pancreatic Cancer Case-Control Consortium genome-wide association studies. Additional exploratory multifactorial scores were constructed by complementing the genetic score with smoking and diabetes.The scores were associated with increased PDAC risk and reached high statistical significance (OR=2.70, 95% CI 1.99 to 3.68, p=2.54×10-10 highest vs lowest quintile of the weighted PRS, and OR=14.37, 95% CI 5.57 to 37.09, p=3.64×10-8, highest vs lowest quintile of the weighted multifactorial score).We found a highly significant association between a PRS and PDAC risk, which explains more than individual SNPs and is a step forward in the direction of the construction of a tool for risk stratification in the population.
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000156769 7001_ $$aNeoptolemos, John P$$b4
000156769 7001_ $$aPasquali, Claudio$$b5
000156769 7001_ $$aNentwich, Michael$$b6
000156769 7001_ $$aCavestro, Giulia Martina$$b7
000156769 7001_ $$aPezzilli, Raffaele$$b8
000156769 7001_ $$aGreenhalf, William$$b9
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000156769 7001_ $$aSchroeder, Cornelia$$b11
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000156769 7001_ $$aIvanauskas, Audrius$$b13
000156769 7001_ $$aGinocchi, Laura$$b14
000156769 7001_ $$aKey, Timothy J$$b15
000156769 7001_ $$aHegyi, Péter$$b16
000156769 7001_ $$aArchibugi, Livia$$b17
000156769 7001_ $$aDarvasi, Erika$$b18
000156769 7001_ $$aBasso, Daniela$$b19
000156769 7001_ $$aSperti, Cosimo$$b20
000156769 7001_ $$aBijlsma, Maarten F$$b21
000156769 7001_ $$00000-0002-0019-7929$$aPalmieri, Orazio$$b22
000156769 7001_ $$aHlavac, Viktor$$b23
000156769 7001_ $$aTalar-Wojnarowska, Renata$$b24
000156769 7001_ $$aMohelnikova-Duchonova, Beatrice$$b25
000156769 7001_ $$aHackert, Thilo$$b26
000156769 7001_ $$aVashist, Yogesh$$b27
000156769 7001_ $$aStrouhal, Ondrej$$b28
000156769 7001_ $$avan Laarhoven, Hanneke$$b29
000156769 7001_ $$aTavano, Francesca$$b30
000156769 7001_ $$aLovecek, Martin$$b31
000156769 7001_ $$aDervenis, Christos$$b32
000156769 7001_ $$aIzbéki, Ferenc$$b33
000156769 7001_ $$aPadoan, Andrea$$b34
000156769 7001_ $$aMałecka-Panas, Ewa$$b35
000156769 7001_ $$aMaiello, Evaristo$$b36
000156769 7001_ $$aVanella, Giuseppe$$b37
000156769 7001_ $$aCapurso, Gabriele$$b38
000156769 7001_ $$aIzbicki, Jakob R$$b39
000156769 7001_ $$aTheodoropoulos, George E$$b40
000156769 7001_ $$aJamroziak, Krzysztof$$b41
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000156769 7001_ $$aMambrini, Andrea$$b44
000156769 7001_ $$aPapanikolaou, Ioannis S$$b45
000156769 7001_ $$aSzmola, Richárd$$b46
000156769 7001_ $$aSzentesi, Andrea$$b47
000156769 7001_ $$aKupcinskas, Juozas$$b48
000156769 7001_ $$aBursi, Simona$$b49
000156769 7001_ $$aCostello, Eithne$$b50
000156769 7001_ $$aBoggi, Ugo$$b51
000156769 7001_ $$aMilanetto, Anna Caterina$$b52
000156769 7001_ $$aLandi, Stefano$$b53
000156769 7001_ $$00000-0002-3295-6811$$aGazouli, Maria$$b54
000156769 7001_ $$aVodickova, Ludmila$$b55
000156769 7001_ $$aSoucek, Pavel$$b56
000156769 7001_ $$aGioffreda, Domenica$$b57
000156769 7001_ $$aGemignani, Federica$$b58
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000156769 7001_ $$aBüchler, Markus$$b61
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000156769 7001_ $$aCampa, Daniele$$b65
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