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@ARTICLE{Triki:156805,
      author       = {M. Triki and G. Rinaldi and M. Planque and D. Broekaert and
                      A. M. Winkelkotte$^*$ and C. R. Maier and S. Janaki Raman
                      and A. Vandekeere and J. Van Elsen and M. F. Orth and T. G.
                      P. Grünewald$^*$ and A. Schulze$^*$ and S.-M. Fendt},
      title        = {m{TOR} {S}ignaling and {SREBP} {A}ctivity {I}ncrease
                      {FADS}2 {E}xpression and {C}an {A}ctivate {S}apienate
                      {B}iosynthesis.},
      journal      = {Cell reports},
      volume       = {31},
      number       = {12},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01122},
      pages        = {107806},
      year         = {2020},
      abstract     = {Cancer cells display an increased plasticity in their lipid
                      metabolism, which includes the conversion of palmitate to
                      sapienate via the enzyme fatty acid desaturase 2 (FADS2). We
                      find that FADS2 expression correlates with mammalian target
                      of rapamycin (mTOR) signaling and sterol regulatory
                      element-binding protein 1 (SREBP-1) activity across multiple
                      cancer types and is prognostic in some cancer types.
                      Accordingly, activating mTOR signaling by deleting tuberous
                      sclerosis complex 2 (Tsc2) or overexpression of SREBP-1/2 is
                      sufficient to increase FADS2 mRNA expression and sapienate
                      metabolism in mouse embryonic fibroblasts (MEFs) and U87
                      glioblastoma cells, respectively. Conversely, inhibiting
                      mTOR signaling decreases FADS2 expression and sapienate
                      biosynthesis in MEFs with Tsc2 deletion, HUH7 hepatocellular
                      carcinoma cells, and orthotopic HUH7 liver xenografts. In
                      conclusion, we show that mTOR signaling and SREBP activity
                      are sufficient to activate sapienate metabolism by
                      increasing FADS2 expression. Consequently, targeting mTOR
                      signaling can reduce sapienate metabolism in vivo.},
      cin          = {A410 / B410 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331 / I:(DE-He78)B410-20160331 /
                      I:(DE-He78)MU01-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32579932},
      doi          = {10.1016/j.celrep.2020.107806},
      url          = {https://inrepo02.dkfz.de/record/156805},
}