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@ARTICLE{Sachpekidis:156826,
      author       = {C. Sachpekidis$^*$ and A. Kopp-Schneider$^*$ and M. Merz
                      and A. Jauch and M.-S. Raab and H. Goldschmidt and A.
                      Dimitrakopoulou-Strauss$^*$},
      title        = {{C}an 18{F}-{N}a{F} {PET}/{CT} before {A}utologous {S}tem
                      {C}ell {T}ransplantation {P}redict {S}urvival in {M}ultiple
                      {M}yeloma?},
      journal      = {Cancers},
      volume       = {12},
      number       = {5},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-01143},
      pages        = {1335},
      year         = {2020},
      note         = {#EA:E060#LA:E060#},
      abstract     = {There is an unmet need for positron emission tomography
                      (PET) radiotracers that can image bone disease in multiple
                      myeloma (MM) in a more sensitive and specific way than the
                      widely used 18F-fluorodeoxyglucose (18F-FDG). Sodium
                      fluoride (18F-NaF) is a highly sensitive tracer of bone
                      reconstruction, evolving as an important imaging agent for
                      the assessment of malignant bone diseases. We attempted to
                      investigate for the first time the prognostic significance
                      of 18F-NaF PET/CT in newly diagnosed, symptomatic MM
                      patients planned for autologous stem cell transplantation
                      (ASCT). Forty-seven patients underwent dynamic and static
                      PET/CT with 18F-NaF before treatment. After correlation with
                      the respective findings on CT and 18F-FDG PET/CT that served
                      as reference, the 18F-NaF PET findings were compared with
                      established factors of high-risk disease, like cytogenetic
                      abnormalities as well as bone marrow plasma cell
                      infiltration rate. Furthermore, the impact of 18F-NaF PET/CT
                      on progression-free survival (PFS) was analyzed. Correlation
                      analysis revealed a moderate, significant correlation of the
                      18F-NaF parameters SUVaverage and K1 in reference tissue
                      with bone marrow plasma cell infiltration rate. However, no
                      significant correlation was observed regarding all other
                      18F-NaF PET parameters. Survival analysis revealed that
                      patients with a pathologic 18F-NaF PET/CT have a shorter PFS
                      (median = 36.2 months) than those with a physiologic scan
                      (median = 55.6 months) (p = 0.02). Nevertheless, no
                      quantitative 18F-NaF parameter could be shown to adversely
                      affect PFS. In contrast, the respective analysis for
                      quantitative dynamic 18F-FDG PET/CT revealed that the
                      parameters SUVmax, fractional blood volume (VB), k3 and
                      influx from reference tissue as well as SUVaverage from MM
                      lesions had a significant negative impact on patient
                      survival. The herein presented findings highlight the rather
                      limited role of 18F-NaF PET/CT as a single PET approach in
                      MM.},
      cin          = {E060 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)E060-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32456181},
      pmc          = {pmc:PMC7281312},
      doi          = {10.3390/cancers12051335},
      url          = {https://inrepo02.dkfz.de/record/156826},
}