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000156841 0247_ $$2ISSN$$a1532-1827
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000156841 037__ $$aDKFZ-2020-01158
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000156841 1001_ $$aMartins, Filipe Correia$$b0
000156841 245__ $$aClinical and pathological associations of PTEN expression in ovarian cancer: a multicentre study from the Ovarian Tumour Tissue Analysis Consortium.
000156841 260__ $$aEdinburgh$$bNature Publ. Group$$c2020
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000156841 500__ $$a2020 Sep;123(5):793-802
000156841 520__ $$aPTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression as a biomarker in epithelial ovarian cancer in a large population-based study.Tumours from 5400 patients from a multicentre observational, prospective cohort study of the Ovarian Tumour Tissue Analysis Consortium were used to evaluate associations between immunohistochemical PTEN patterns and overall survival time, age, stage, grade, residual tumour, CD8+ tumour-infiltrating lymphocytes (TIL) counts, expression of oestrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) by means of Cox proportional hazard models and generalised Cochran-Mantel-Haenszel tests.Downregulation of cytoplasmic PTEN expression was most frequent in ENOC (most frequently in younger patients; p value = 0.0001) and CCOC and was associated with longer overall survival in HGSOC (hazard ratio: 0.78, 95% CI: 0.65-0.94, p value = 0.022). PTEN expression was associated with ER, PR and AR expression (p values: 0.0008, 0.062 and 0.0002, respectively) in HGSOC and with lower CD8 counts in CCOC (p value < 0.0001). Heterogeneous expression of PTEN was more prevalent in advanced HGSOC (p value = 0.019) and associated with higher CD8 counts (p value = 0.0016).PTEN loss is a frequent driver in ovarian carcinoma associating distinctly with expression of hormonal receptors and CD8+ TIL counts in HGSOC and CCOC histotypes.
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000156841 7001_ $$aCouturier, Dominique-Laurent$$b1
000156841 7001_ $$aPaterson, Anna$$b2
000156841 7001_ $$aKarnezis, Anthony N$$b3
000156841 7001_ $$aChow, Christine$$b4
000156841 7001_ $$aNazeran, Tayyebeh M$$b5
000156841 7001_ $$aOdunsi, Adekunle$$b6
000156841 7001_ $$aGentry-Maharaj, Aleksandra$$b7
000156841 7001_ $$aVrvilo, Aleksandra$$b8
000156841 7001_ $$aHein, Alexander$$b9
000156841 7001_ $$aTalhouk, Aline$$b10
000156841 7001_ $$aOsorio, Ana$$b11
000156841 7001_ $$aHartkopf, Andreas D$$b12
000156841 7001_ $$aBrooks-Wilson, Angela$$b13
000156841 7001_ $$aDeFazio, Anna$$b14
000156841 7001_ $$aFischer, Anna$$b15
000156841 7001_ $$aHartmann, Arndt$$b16
000156841 7001_ $$aHernandez, Brenda Y$$b17
000156841 7001_ $$aMcCauley, Bryan M$$b18
000156841 7001_ $$aKarpinskyj, Chloe$$b19
000156841 7001_ $$ade Sousa, Christiani B$$b20
000156841 7001_ $$aHøgdall, Claus$$b21
000156841 7001_ $$aTiezzi, Daniel G$$b22
000156841 7001_ $$aHerpel, Esther$$b23
000156841 7001_ $$aTaran, Florin Andrei$$b24
000156841 7001_ $$aModugno, Francesmary$$b25
000156841 7001_ $$aKeeney, Gary$$b26
000156841 7001_ $$aNelson, Gregg$$b27
000156841 7001_ $$aSteed, Helen$$b28
000156841 7001_ $$aSong, Honglin$$b29
000156841 7001_ $$aLuk, Hugh$$b30
000156841 7001_ $$aBenitez, Javier$$b31
000156841 7001_ $$aAlsop, Jennifer$$b32
000156841 7001_ $$aKoziak, Jennifer M$$b33
000156841 7001_ $$aLester, Jenny$$b34
000156841 7001_ $$aRothstein, Joseph H$$b35
000156841 7001_ $$ade Andrade, Jurandyr M$$b36
000156841 7001_ $$aLundvall, Lene$$b37
000156841 7001_ $$aPaz-Ares, Luis$$b38
000156841 7001_ $$aRobles-Díaz, Luis$$b39
000156841 7001_ $$aWilkens, Lynne R$$b40
000156841 7001_ $$aGarcia, Maria J$$b41
000156841 7001_ $$aIntermaggio, Maria P$$b42
000156841 7001_ $$aAlcaraz, Marie-Lyne$$b43
000156841 7001_ $$aBrett, Mary A$$b44
000156841 7001_ $$aBeckmann, Matthias W$$b45
000156841 7001_ $$aJimenez-Linan, Mercedes$$b46
000156841 7001_ $$aAnglesio, Michael$$b47
000156841 7001_ $$aCarney, Michael E$$b48
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000156841 7001_ $$aTraficante, Nadia$$b50
000156841 7001_ $$aPejovic, Nadja$$b51
000156841 7001_ $$aSingh, Naveena$$b52
000156841 7001_ $$aLe, Nhu$$b53
000156841 7001_ $$aSinn, Peter$$b54
000156841 7001_ $$aGhatage, Prafull$$b55
000156841 7001_ $$aErber, Ramona$$b56
000156841 7001_ $$aEdwards, Robert$$b57
000156841 7001_ $$aVierkant, Robert$$b58
000156841 7001_ $$aNess, Roberta B$$b59
000156841 7001_ $$aLeung, Samuel$$b60
000156841 7001_ $$aOrsulic, Sandra$$b61
000156841 7001_ $$aBrucker, Sara Y$$b62
000156841 7001_ $$aKaufmann, Scott H$$b63
000156841 7001_ $$aFereday, Sian$$b64
000156841 7001_ $$aGayther, Simon$$b65
000156841 7001_ $$aWinham, Stacey J$$b66
000156841 7001_ $$aKommoss, Stefan$$b67
000156841 7001_ $$aPejovic, Tanja$$b68
000156841 7001_ $$aLongacre, Teri A$$b69
000156841 7001_ $$aMcGuire, Valerie$$b70
000156841 7001_ $$aRhenius, Valerie$$b71
000156841 7001_ $$aSieh, Weiva$$b72
000156841 7001_ $$aShvetsov, Yurii B$$b73
000156841 7001_ $$aWhittemore, Alice S$$b74
000156841 7001_ $$aStaebler, Annette$$b75
000156841 7001_ $$aKarlan, Beth Y$$b76
000156841 7001_ $$aRodriguez-Antona, Cristina$$b77
000156841 7001_ $$aBowtell, David D$$b78
000156841 7001_ $$aGoode, Ellen L$$b79
000156841 7001_ $$aHøgdall, Estrid$$b80
000156841 7001_ $$00000-0001-5758-5917$$aCandido Dos Reis, Francisco J$$b81
000156841 7001_ $$aGronwald, Jacek$$b82
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000156841 7001_ $$aKelemen, Linda E$$b85
000156841 7001_ $$aCook, Linda S$$b86
000156841 7001_ $$aGoodman, Marc T$$b87
000156841 7001_ $$aFasching, Peter A$$b88
000156841 7001_ $$aCrawford, Robin$$b89
000156841 7001_ $$aDeen, Suha$$b90
000156841 7001_ $$aMenon, Usha$$b91
000156841 7001_ $$aHuntsman, David G$$b92
000156841 7001_ $$aKöbel, Martin$$b93
000156841 7001_ $$aRamus, Susan J$$b94
000156841 7001_ $$aPharoah, Paul D P$$b95
000156841 7001_ $$00000-0002-5738-6683$$aBrenton, James D$$b96
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