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@ARTICLE{Martins:156841,
      author       = {F. C. Martins and D.-L. Couturier and A. Paterson and A. N.
                      Karnezis and C. Chow and T. M. Nazeran and A. Odunsi and A.
                      Gentry-Maharaj and A. Vrvilo and A. Hein and A. Talhouk and
                      A. Osorio and A. D. Hartkopf and A. Brooks-Wilson and A.
                      DeFazio and A. Fischer and A. Hartmann and B. Y. Hernandez
                      and B. M. McCauley and C. Karpinskyj and C. B. de Sousa and
                      C. Høgdall and D. G. Tiezzi and E. Herpel and F. A. Taran
                      and F. Modugno and G. Keeney and G. Nelson and H. Steed and
                      H. Song and H. Luk and J. Benitez and J. Alsop and J. M.
                      Koziak and J. Lester and J. H. Rothstein and J. M. de
                      Andrade and L. Lundvall and L. Paz-Ares and L. Robles-Díaz
                      and L. R. Wilkens and M. J. Garcia and M. P. Intermaggio and
                      M.-L. Alcaraz and M. A. Brett and M. W. Beckmann and M.
                      Jimenez-Linan and M. Anglesio and M. E. Carney and M.
                      Schneider and N. Traficante and N. Pejovic and N. Singh and
                      N. Le and P. Sinn and P. Ghatage and R. Erber and R. Edwards
                      and R. Vierkant and R. B. Ness and S. Leung and S. Orsulic
                      and S. Y. Brucker and S. H. Kaufmann and S. Fereday and S.
                      Gayther and S. J. Winham and S. Kommoss and T. Pejovic and
                      T. A. Longacre and V. McGuire and V. Rhenius and W. Sieh and
                      Y. B. Shvetsov and A. S. Whittemore and A. Staebler and B.
                      Y. Karlan and C. Rodriguez-Antona and D. D. Bowtell and E.
                      L. Goode and E. Høgdall and F. J. Candido Dos Reis and J.
                      Gronwald and J. Chang-Claude$^*$ and K. B. Moysich and L. E.
                      Kelemen and L. S. Cook and M. T. Goodman and P. A. Fasching
                      and R. Crawford and S. Deen and U. Menon and D. G. Huntsman
                      and M. Köbel and S. J. Ramus and P. D. P. Pharoah and J. D.
                      Brenton},
      title        = {{C}linical and pathological associations of {PTEN}
                      expression in ovarian cancer: a multicentre study from the
                      {O}varian {T}umour {T}issue {A}nalysis {C}onsortium.},
      journal      = {British journal of cancer},
      volume       = {123},
      number       = {5},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2020-01158},
      pages        = {793-802},
      year         = {2020},
      note         = {2020 Sep;123(5):793-802},
      abstract     = {PTEN loss is a putative driver in histotypes of ovarian
                      cancer (high-grade serous (HGSOC), endometrioid (ENOC),
                      clear cell (CCOC), mucinous (MOC), low-grade serous
                      (LGSOC)). We aimed to characterise PTEN expression as a
                      biomarker in epithelial ovarian cancer in a large
                      population-based study.Tumours from 5400 patients from a
                      multicentre observational, prospective cohort study of the
                      Ovarian Tumour Tissue Analysis Consortium were used to
                      evaluate associations between immunohistochemical PTEN
                      patterns and overall survival time, age, stage, grade,
                      residual tumour, CD8+ tumour-infiltrating lymphocytes (TIL)
                      counts, expression of oestrogen receptor (ER), progesterone
                      receptor (PR) and androgen receptor (AR) by means of Cox
                      proportional hazard models and generalised
                      Cochran-Mantel-Haenszel tests.Downregulation of cytoplasmic
                      PTEN expression was most frequent in ENOC (most frequently
                      in younger patients; p value = 0.0001) and CCOC and was
                      associated with longer overall survival in HGSOC (hazard
                      ratio: 0.78, $95\%$ CI: 0.65-0.94, p value = 0.022).
                      PTEN expression was associated with ER, PR and AR expression
                      (p values: 0.0008, 0.062 and 0.0002, respectively) in HGSOC
                      and with lower CD8 counts in CCOC (p value < 0.0001).
                      Heterogeneous expression of PTEN was more prevalent in
                      advanced HGSOC (p value = 0.019) and associated with
                      higher CD8 counts (p value = 0.0016).PTEN loss is a
                      frequent driver in ovarian carcinoma associating distinctly
                      with expression of hormonal receptors and CD8+ TIL counts in
                      HGSOC and CCOC histotypes.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32555365},
      doi          = {10.1038/s41416-020-0900-0},
      url          = {https://inrepo02.dkfz.de/record/156841},
}