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| Home > Publications database > Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE). > print |
| 001 | 156842 | ||
| 005 | 20240229123118.0 | ||
| 024 | 7 | _ | |a 10.1158/1078-0432.CCR-20-0103 |2 doi |
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| 100 | 1 | _ | |a Talhouk, Aline |0 0000-0001-7760-410X |b 0 |
| 245 | _ | _ | |a Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE). |
| 260 | _ | _ | |a Philadelphia, Pa. [u.a.] |c 2020 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1606134138_2611 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 Oct 15;26(20):5411-5423 |
| 520 | _ | _ | |a Gene-expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by non-standardized methods which are not applicable in a clinical setting. We sought to generate a clinical-grade minimal gene-set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously reported subtype-associated features.Adopting two independent approaches, we derived and internally validated algorithms for subtype prediction using published gene-expression data from 1650 tumors. We applied resulting models to NanoString data on 3829 HGSOCs from the Ovarian Tumor Tissue Analysis Consortium. We further developed, confirmed, and validated a reduced, minimal gene-set predictor, with methods suitable for a single patient setting.Gene-expression data was used to derive the Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE) assay. We established a de facto standard as a consensus of two parallel approaches. PrOTYPE subtypes are significantly associated with age, stage, residual disease, tumor infiltrating lymphocytes, and outcome. The locked-down clinical-grade PrOTYPE test includes a model with 55 genes that predicted gene-expression subtype with >95% accuracy that was maintained in all analytical and biological validations.We validated the PrOTYPE assay following the Institute of Medicine guidelines for the development of omics-based tests. This fully defined and locked-down clinical-grade assay will enable trial design with molecular subtype stratification and allow for objective assessment of the predictive value of HGSOC molecular subtypes in precision medicine applications. |
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| 700 | 1 | _ | |a Wang, Chen |0 0000-0003-2638-3081 |b 2 |
| 700 | 1 | _ | |a Budden, Timothy |b 3 |
| 700 | 1 | _ | |a Tan, Tuan Zea |0 0000-0001-6624-1593 |b 4 |
| 700 | 1 | _ | |a Chiu, Derek S |b 5 |
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| 700 | 1 | _ | |a Chen, Stephanie |b 8 |
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| 700 | 1 | _ | |a Liu, Geyi |b 21 |
| 700 | 1 | _ | |a Johnson, Dustin |b 22 |
| 700 | 1 | _ | |a Chen, Billy |b 23 |
| 700 | 1 | _ | |a Ovarian Cancer Study, Australian |b 24 |
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