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@ARTICLE{Zhang:156849,
author = {Y. D. Zhang and A. N. Hurson and H. Zhang and P. P.
Choudhury and D. F. Easton and R. L. Milne and J. Simard and
P. Hall and K. Michailidou and J. Dennis and M. K. Schmidt
and J. Chang-Claude$^*$ and P. Gharahkhani and D. Whiteman
and P. T. Campbell and M. Hoffmeister$^*$ and M. Jenkins and
U. Peters and L. Hsu and S. B. Gruber and G. Casey and S. L.
Schmit and T. A. O'Mara and A. B. Spurdle and D. J. Thompson
and I. Tomlinson and I. De Vivo and M. T. Landi and M. H.
Law and M. M. Iles and F. Demenais and R. Kumar$^*$ and S.
MacGregor and D. T. Bishop and S. V. Ward and M. L. Bondy
and R. Houlston and J. K. Wiencke and B. Melin and J.
Barnholtz-Sloan and B. Kinnersley and M. R. Wrensch and C.
I. Amos and R. J. Hung and P. Brennan and J. McKay and N. E.
Caporaso and S. I. Berndt and B. M. Birmann and N. J. Camp
and P. Kraft and N. Rothman and S. L. Slager and A. Berchuck
and P. D. P. Pharoah and T. A. Sellers and S. A. Gayther and
C. L. Pearce and E. L. Goode and J. M. Schildkraut and K. B.
Moysich and L. T. Amundadottir and E. J. Jacobs and A. P.
Klein and G. M. Petersen and H. A. Risch and R. Z.
Stolzenberg-Solomon and B. M. Wolpin and D. Li and R. A.
Eeles and C. A. Haiman and Z. Kote-Jarai and F. R.
Schumacher and A. A. Al Olama and M. P. Purdue and G. Scelo
and M. D. Dalgaard and M. H. Greene and T. Grotmol and P. A.
Kanetsky and K. A. McGlynn and K. L. Nathanson and C.
Turnbull and F. Wiklund and S. J. Chanock and N. Chatterjee
and M. Garcia-Closas and D. F. Easton and R. L. Milne and J.
Simard and P. Hall and K. Michailidou and J. Dennis and M.
K. Schmidt and J. Chang-Claude$^*$ and P. Gharahkhani and D.
Whiteman and P. T. Campbell and M. Hoffmeister$^*$ and M.
Jenkins and U. Peters and L. Hsu and S. B. Gruber and G.
Casey and S. L. Schmit and P. T. Campbell and M.
Hoffmeister$^*$ and M. Jenkins and U. Peters and L. Hsu and
S. B. Gruber and G. Casey and S. L. Schmit and T. A. O'Mara
and A. B. Spurdle and D. J. Thompson and I. Tomlinson and I.
De Vivo and P. T. Campbell and M. Hoffmeister$^*$ and M.
Jenkins and U. Peters and L. Hsu and S. B. Gruber and G.
Casey and S. L. Schmit and M. T. Landi and M. H. Law and M.
M. Iles and F. Demenais and R. Kumar$^*$ and S. MacGregor
and D. T. Bishop and S. V. Ward and M. L. Bondy and R.
Houlston and J. K. Wiencke and B. Melin and J.
Barnholtz-Sloan and B. Kinnersley and M. R. Wrensch and C.
I. Amos and R. J. Hung and P. Brennan and J. McKay and N. E.
Caporaso and C. I. Amos and R. J. Hung and P. Brennan and J.
McKay and N. E. Caporaso and S. I. Berndt and B. M. Birmann
and N. J. Camp and P. Kraft and N. Rothman and S. L. Slager
and A. Berchuck and P. D. P. Pharoah and T. A. Sellers and
S. A. Gayther and C. L. Pearce and E. L. Goode and J. M.
Schildkraut and K. B. Moysich and C. I. Amos and P. Brennan
and J. McKay and L. T. Amundadottir and E. J. Jacobs and A.
P. Klein and G. M. Petersen and H. A. Risch and R. Z.
Stolzenberg-Solomon and B. M. Wolpin and D. Li and L. T.
Amundadottir and E. J. Jacobs and A. P. Klein and G. M.
Petersen and H. A. Risch and R. Z. Stolzenberg-Solomon and
B. M. Wolpin and D. Li and R. A. Eeles and C. A. Haiman and
Z. Kote-Jarai and F. R. Schumacher and A. A. Al Olama and M.
P. Purdue and G. Scelo and M. D. Dalgaard and M. H. Greene
and T. Grotmol and P. A. Kanetsky and K. A. McGlynn and K.
L. Nathanson and C. Turnbull and F. Wiklund},
collaboration = {B. C. A. Consortium and B. a. E. A. Consortium and C. C. F.
Registry and T. S. o. G. V. i. C. Cancer and E. C. A.
Consortium and G. a. E. o. C. C. Consortium and M. G.
Consortium and G. I. C. Study and I. L. C. Consortium and I.
A. o. L. C. E. a. Risk and I. C. o. I. W. o. N. L. E.
Studies and O. C. A. Consortium and O. C. GWAS and P. C. C.
Consortium and P. C. C. Consortium and P. C. A. G. t. I. C.
A. A. i. t. Genome and R. C. GWAS and T. C. Consortium},
title = {{A}ssessment of polygenic architecture and risk prediction
based on common variants across fourteen cancers.},
journal = {Nature Communications},
volume = {11},
number = {1},
issn = {2041-1723},
address = {[London]},
publisher = {Nature Publishing Group UK},
reportid = {DKFZ-2020-01166},
pages = {3353},
year = {2020},
abstract = {Genome-wide association studies (GWAS) have led to the
identification of hundreds of susceptibility loci across
cancers, but the impact of further studies remains
uncertain. Here we analyse summary-level data from GWAS of
European ancestry across fourteen cancer sites to estimate
the number of common susceptibility variants (polygenicity)
and underlying effect-size distribution. All cancers show a
high degree of polygenicity, involving at a minimum of
thousands of loci. We project that sample sizes required to
explain $80\%$ of GWAS heritability vary from 60,000 cases
for testicular to over 1,000,000 cases for lung cancer. The
maximum relative risk achievable for subjects at the 99th
risk percentile of underlying polygenic risk scores (PRS),
compared to average risk, ranges from 12 for testicular to
2.5 for ovarian cancer. We show that PRS have potential for
risk stratification for cancers of breast, colon and
prostate, but less so for others because of modest
heritability and lower incidence.},
cin = {C020 / C070 / C050 / B070},
ddc = {500},
cid = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
I:(DE-He78)C050-20160331 / I:(DE-He78)B070-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:32620889},
doi = {10.1038/s41467-020-16483-3},
url = {https://inrepo02.dkfz.de/record/156849},
}
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