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000156857 0247_ $$2ISSN$$a1938-3207
000156857 0247_ $$2ISSN$$a1938-3215
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000156857 041__ $$aeng
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000156857 1001_ $$aSieri, Sabina$$b0
000156857 245__ $$aGlycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study.
000156857 260__ $$aOxford$$bOxford University Press$$c2020
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000156857 500__ $$a2020 Sep 1;112(3):631-643
000156857 520__ $$aHigh carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk.The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes.This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models.After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) ≥25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI <25 [HR: 1.09 (95% CI: 0.98, 1.22) per 50 g/d) (P-interaction = 0.022). The GL-CHD association did not differ between men [HR: 1.19 (95% CI: 1.08, 1.30) per 50 g/d] and women [HR: 1.22 (95% CI: 1.07, 1.40) per 50 g/d] (test for interaction not significant). GI was associated with CHD risk only in the continuous model [HR: 1.04 (95% CI: 1.00, 1.08) per 5 units/d]. High available carbohydrate was associated with greater CHD risk [HR: 1.11 (95% CI: 1.03, 1.18) per 50 g/d]. High sugar intake was associated with greater CHD risk [HR: 1.09 (95% CI: 1.02, 1.17) per 50 g/d].This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.
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000156857 7001_ $$aAgnoli, Claudia$$b1
000156857 7001_ $$aGrioni, Sara$$b2
000156857 7001_ $$aWeiderpass, Elisabete$$b3
000156857 7001_ $$aMattiello, Amalia$$b4
000156857 7001_ $$aSluijs, Ivonne$$b5
000156857 7001_ $$aSanchez, Maria Jose$$b6
000156857 7001_ $$aJakobsen, Marianne Uhre$$b7
000156857 7001_ $$aSweeting, Michael$$b8
000156857 7001_ $$avan der Schouw, Yvonne T$$b9
000156857 7001_ $$aNilsson, Lena Maria$$b10
000156857 7001_ $$aWennberg, Patrik$$b11
000156857 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena A$$b12$$udkfz
000156857 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b13$$udkfz
000156857 7001_ $$aOvervad, Kim$$b14
000156857 7001_ $$aTong, Tammy Y N$$b15
000156857 7001_ $$aConchi, Moreno-Iribas$$b16
000156857 7001_ $$aQuirós, José Ramón$$b17
000156857 7001_ $$aGarcía-Torrecillas, Juan Manuel$$b18
000156857 7001_ $$aMokoroa, Olatz$$b19
000156857 7001_ $$aGómez, Jesús-Humberto$$b20
000156857 7001_ $$aTjønneland, Anne$$b21
000156857 7001_ $$aSonestedt, Emiliy$$b22
000156857 7001_ $$aTrichopoulou, Antonia$$b23
000156857 7001_ $$aKarakatsani, Anna$$b24
000156857 7001_ $$aValanou, Elissavet$$b25
000156857 7001_ $$aBoer, Jolanda M A$$b26
000156857 7001_ $$aVerschuren, W M Monique$$b27
000156857 7001_ $$aBoutron-Ruault, Marie-Christine$$b28
000156857 7001_ $$aFagherazzi, Guy$$b29
000156857 7001_ $$aMadika, Anne-Laure$$b30
000156857 7001_ $$aBergmann, Manuela M$$b31
000156857 7001_ $$aSchulze, Matthias B$$b32
000156857 7001_ $$aFerrari, Pietro$$b33
000156857 7001_ $$aFreisling, Heinz$$b34
000156857 7001_ $$aLennon, Hannah$$b35
000156857 7001_ $$aSacerdote, Carlotta$$b36
000156857 7001_ $$aMasala, Giovanna$$b37
000156857 7001_ $$aTumino, Rosario$$b38
000156857 7001_ $$aRiboli, Elio$$b39
000156857 7001_ $$aWareham, Nicholas J$$b40
000156857 7001_ $$aDanesh, John$$b41
000156857 7001_ $$aForouhi, Nita G$$b42
000156857 7001_ $$aButterworth, Adam S$$b43
000156857 7001_ $$aKrogh, Vittorio$$b44
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