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@ARTICLE{Yammine:156859,
      author       = {S. Yammine and I. Huybrechts and C. Biessy and L. Dossus
                      and E. K. Aglago and S. Naudin and P. Ferrari and E.
                      Weiderpass and A. Tjonneland and L. Hansen and K. Overvad
                      and F. Romana Mancini and M.-C. Boutron-Ruault and M.
                      Kvaskoff and R. Turzanski-Fortner$^*$ and R. Kaaks$^*$ and
                      M. B. Schulze and H. Boing and A. Trichopoulou and A.
                      Karakatsani and C. La Vecchia and V. Benetou and G. Masala
                      and V. Krogh and A. Mattiello and A. Macciotta and I. T.
                      Gram and G. Skeie and J. R. Quiros Garcia and A. Agudo and
                      M.-J. Sanchez-Perez and M.-D. Chirlaque and E. Ardanaz and
                      L. Gil and H. Sartor and I. Drake and A. Idahl and E. A.
                      Lundin and D. Aune and H. A. Ward and M. A. Merritt and N.
                      E. Allen and M. J. Gunter and V. Chajes},
      title        = {{D}ietary and circulating fatty acids and ovarian cancer
                      risk in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {9},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-01176},
      pages        = {1739-1749},
      year         = {2020},
      note         = {2020 Sep;29(9):1739-1749},
      abstract     = {Fatty acids impact obesity, estrogens and inflammation,
                      risk factors for ovarian cancer. Few epidemiological studies
                      have investigated the association of fatty acids with
                      ovarian cancer.Within the European Prospective Investigation
                      into Cancer and nutrition, 1,486 incident ovarian cancer
                      cases were identified. Cox Proportional Hazard models with
                      adjustment for ovarian cancer risk factors were used to
                      estimate hazard ratios of ovarian cancer across quintiles of
                      intake of fatty acids. False discovery rate was computed to
                      control for multiple testing. Multivariable conditional
                      logistic regression models were used to estimate odds ratios
                      of ovarian cancer across tertiles of plasma fatty acids
                      among 633 cases and two matched controls in a nested
                      case-control analysis.A positive association was found
                      between ovarian cancer and intake of industrial trans
                      elaidic acid (Hazard Ratio comparing 5th with 1st
                      quintileQ5-Q1=1.29; $95\%$ CI=1.03-1.62; ptrend=0.02,
                      q-value=0.06). Dietary intakes of n-6 linoleic acid
                      (HRQ5-Q1=1.10; $95\%$ CI=1.01-1.21; ptrend=0.03) and n-3
                      α-linolenic acid (HRQ5-Q1=1.18; $95\%$ CI=1.05-1.34;
                      ptrend=0.007) from deep frying fats were also positively
                      associated with ovarian cancer. Suggestive associations were
                      reported for circulating elaidic (Odds Ratio comparing 3rd
                      with 1st tertileT3-T1 = 1.39; $95\%$ CI=0.99-1.94;
                      ptrend=0.06) and α-linolenic acids (ORT3-T1=1.30; $95\%$
                      CI=0.98-1.72; ptrend=0.06).Our results suggest that higher
                      intakes and circulating levels of industrial trans elaidic
                      acid, and higher intakes of linoleic acid and α-linolenic
                      acid from deep frying fat, may be associated with greater
                      risk of ovarian cancer.If causal, eliminating industrial
                      trans fatty acids could offer a straightforward public
                      health action for reducing ovarian cancer.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32616494},
      doi          = {10.1158/1055-9965.EPI-19-1477},
      url          = {https://inrepo02.dkfz.de/record/156859},
}