% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Liu:156863,
      author       = {J. Liu and W. J. C. Prager-van der Smissen and J. M.
                      Collée and M. K. Bolla and Q. Wang and K. Michailidou and
                      J. Dennis and T. U. Ahearn and K. Aittomäki and C. B.
                      Ambrosone and I. L. Andrulis and H. Anton-Culver and N. N.
                      Antonenkova and V. Arndt$^*$ and N. Arnold and K. J. Aronson
                      and A. Augustinsson and P. Auvinen and H. Becher and M. W.
                      Beckmann and S. Behrens$^*$ and M. Bermisheva and L.
                      Bernstein and N. V. Bogdanova and N. Bogdanova-Markov and S.
                      E. Bojesen and H. Brauch and H. Brenner$^*$ and I. Briceno
                      and S. Y. Brucker and T. Brüning and B. Burwinkel$^*$ and
                      Q. Cai and H. Cai and D. Campa and F. Canzian$^*$ and J. E.
                      Castelao and J. Chang-Claude$^*$ and S. J. Chanock and J.-Y.
                      Choi and M. Christiaens and C. L. Clarke and F. J. Couch and
                      K. Czene and M. B. Daly and P. Devilee and I.
                      Dos-Santos-Silva and M. Dwek and D. M. Eccles and A. H.
                      Eliassen and P. A. Fasching and J. Figueroa and H. Flyger
                      and L. Fritschi and M. Gago-Dominguez and S. M. Gapstur and
                      M. García-Closas and J. A. García-Sáenz and M. M. Gaudet
                      and G. G. Giles and M. S. Goldberg and D. E. Goldgar and P.
                      Guénel and C. A. Haiman and N. Håkansson and P. Hall and
                      P. A. Harrington and S. N. Hart and M. Hartman and P.
                      Hillemanns and J. L. Hopper and M.-F. Hou and D. J. Hunter
                      and D. Huo and H. Ito and M. Iwasaki and M. Jakimovska and
                      A. Jakubowska and E. M. John and R. Kaaks$^*$ and D. Kang
                      and R. Keeman and E. Khusnutdinova and S.-W. Kim and P.
                      Kraft and V. N. Kristensen and A. W. Kurian and L. Le
                      Marchand and J. Li and A. Lindblom and A. Lophatananon and
                      R. N. Luben and J. Lubiński and A. Mannermaa and M.
                      Manoochehri$^*$ and S. Manoukian and S. Margolin and S.
                      Mariapun and K. Matsuo and T. Maurer and D. Mavroudis and A.
                      Meindl and U. Menon and R. L. Milne and K. Muir and A. M.
                      Mulligan and S. L. Neuhausen and H. Nevanlinna and K. Offit
                      and O. I. Olopade and J. E. Olson and H. Olsson and N. Orr
                      and S. K. Park and P. Peterlongo and J. Peto and D.
                      Plaseska-Karanfilska and N. Presneau and B. Rack and R.
                      Rau-Murthy and G. Rennert and H. S. Rennert and V. Rhenius
                      and A. Romero and M. Ruebner and E. Saloustros and R. K.
                      Schmutzler and A. Schneeweiss and C. Scott and M. Shah and
                      C.-Y. Shen and X.-O. Shu and J. Simard and C. Sohn and M. C.
                      Southey and J. J. Spinelli and R. M. Tamimi and W. J. Tapper
                      and S. H. Teo and M. B. Terry and D. Torres and T. Truong
                      and M. Untch and C. M. Vachon and C. J. van Asperen and A.
                      Wolk and T. Yamaji and W. Zheng and A. Ziogas and E. Ziv and
                      G. Torres-Mejía and T. Dörk and A. J. Swerdlow and U.
                      Hamann$^*$ and M. K. Schmidt and A. M. Dunning and P. D. P.
                      Pharoah and D. F. Easton and M. J. Hooning and J. W. M.
                      Martens and A. Hollestelle and K. K. Sahlberg and A.-L.
                      Børresen-Dale and L. Ottestad and R. Kåresen and E.
                      Schlichting and M. M. Holmen and T. Sauer and V. Haakensen
                      and O. Engebråten and B. Naume and A. Fosså and C. E.
                      Kiserud and K. V. Reinertsen and Å. Helland and M. Riis and
                      J. Geisler and G. I. G. Alnæs and C. Clarke and D. Marsh
                      and R. Scott and R. Baxter and D. Yip and J. Carpenter and
                      A. Davis and N. Pathmanathan and P. Simpson and D. Graham
                      and M. Sachchithananthan},
      collaboration = {NBCS Collaborators and A. Investigators},
      title        = {{G}ermline {HOXB}13 mutations p.{G}84{E} and p.{R}217{C} do
                      not confer an increased breast cancer risk.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-01180},
      pages        = {9688},
      year         = {2020},
      abstract     = {In breast cancer, high levels of homeobox protein Hox-B13
                      (HOXB13) have been associated with disease progression of
                      ER-positive breast cancer patients and resistance to
                      tamoxifen treatment. Since HOXB13 p.G84E is a prostate
                      cancer risk allele, we evaluated the association between
                      HOXB13 germline mutations and breast cancer risk in a
                      previous study consisting of 3,270 familial non-BRCA1/2
                      breast cancer cases and 2,327 controls from the Netherlands.
                      Although both recurrent HOXB13 mutations p.G84E and p.R217C
                      were not associated with breast cancer risk, the risk
                      estimation for p.R217C was not very precise. To provide more
                      conclusive evidence regarding the role of HOXB13 in breast
                      cancer susceptibility, we here evaluated the association
                      between HOXB13 mutations and increased breast cancer risk
                      within 81 studies of the international Breast Cancer
                      Association Consortium containing 68,521 invasive breast
                      cancer patients and 54,865 controls. Both HOXB13 p.G84E and
                      p.R217C did not associate with the development of breast
                      cancer in European women, neither in the overall analysis
                      (OR = 1.035, $95\%$ CI = 0.859-1.246, P = 0.718
                      and OR = 0.798, $95\%$ CI = 0.482-1.322,
                      P = 0.381 respectively), nor in specific high-risk
                      subgroups or breast cancer subtypes. Thus, although involved
                      in breast cancer progression, HOXB13 is not a material
                      breast cancer susceptibility gene.},
      cin          = {C071 / C020 / C070 / C120 / TU01 / C080 / C055 / B072 /
                      B070},
      ddc          = {600},
      cid          = {I:(DE-He78)C071-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)TU01-20160331 / I:(DE-He78)C080-20160331 /
                      I:(DE-He78)C055-20160331 / I:(DE-He78)B072-20160331 /
                      I:(DE-He78)B070-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32546843},
      pmc          = {pmc:PMC7297796},
      doi          = {10.1038/s41598-020-65665-y},
      url          = {https://inrepo02.dkfz.de/record/156863},
}