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@ARTICLE{Adam:156899,
      author       = {S. Adam and E. Martin-Diener and B. Camey and C. Egger
                      Hayoz and I. Konzelmann and S. Mohsen Mousavi and C.
                      Herrmann and S. Rohrmann and M. Wanner and K. Staehelin and
                      R. T. Strebel and M. Randazzo and H. John and H.-P. Schmid
                      and V. Arndt$^*$},
      title        = {{H}ealth-related quality of life in long-term prostate
                      cancer survivors after nerve-sparing and non-nerve-sparing
                      radical prostatectomy-{R}esults from the multiregional
                      {PROCAS} study.},
      journal      = {Cancer medicine},
      volume       = {9},
      number       = {15},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2020-01206},
      pages        = {5416-5424},
      year         = {2020},
      note         = {2020 Aug;9(15):5416-5424#LA:C071#},
      abstract     = {Nerve-sparing (NS) surgery was developed to improve
                      postoperative sexual and potentially urological outcomes
                      after radical prostatectomy (RP). However, it is largely
                      unknown how NSRP affects health-related quality of life
                      (HRQoL) including urinary and sexual outcomes in prostate
                      cancer (PC) survivors 5-10 years after diagnosis in
                      comparison with Non-NSRP.The study population included 382
                      stage pT2-T3N0M0 PC survivors 5-10 years post diagnosis,
                      who were identified from the multiregional Prostate Cancer
                      Survivorship in Switzerland (PROCAS) study. Briefly, in
                      2017/2018, PC survivors were identified via six
                      population-based cancer registries based in both German- and
                      French-speaking Switzerland. HRQoL and PC-specific symptom
                      burden was assessed using the EORTC QLQ-C30 and EORTC
                      QLQ-PR25 questionnaires. Differences in HRQoL outcomes
                      between survivors treated with NSRP (uni- $\&$ bilateral)
                      and Non-NSRP were analyzed with multivariable linear
                      regression adjusted for age, years since diagnosis, cancer
                      stage, comorbidities at diagnosis, and further therapies, if
                      appropriate. Multiple imputation was performed to minimize
                      the bias due to missing data.Five to ten years after
                      diagnosis, PC survivors treated with NSRP and Non-NSRP
                      reported similar symptom burden and comparable HRQoL
                      function scores. The only significant differences were
                      reported for sexual activity, whereas PC survivors who
                      underwent NSRP reported statistically significant
                      (P = .031) higher sexual activity than those on Non-NSRP.
                      NSRP and Non-NSRP reported similar scores for urinary
                      symptoms and all other HRQoL outcomes.Our results support
                      nerve-sparing techniques as an option to improve
                      postoperative sexual, but not urinary outcomes after RP in
                      long-term PC survivors.},
      cin          = {C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32524704},
      doi          = {10.1002/cam4.3197},
      url          = {https://inrepo02.dkfz.de/record/156899},
}