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@ARTICLE{Hoffmann:156956,
      author       = {A. Hoffmann and B. Oborn and M. Moteabbed and S. Yan and T.
                      Bortfeld and A. Knopf and H. Fuchs and D. Georg and J.
                      Seco$^*$ and M. F. Spadea and O. Jäkel$^*$ and C. Kurz and
                      K. Parodi},
      title        = {{MR}-guided proton therapy: a review and a preview.},
      journal      = {Radiation oncology},
      volume       = {15},
      number       = {1},
      issn         = {1748-717X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2020-01261},
      pages        = {129},
      year         = {2020},
      abstract     = {The targeting accuracy of proton therapy (PT) for moving
                      soft-tissue tumours is expected to greatly improve by
                      real-time magnetic resonance imaging (MRI) guidance. The
                      integration of MRI and PT at the treatment isocenter would
                      offer the opportunity of combining the unparalleled
                      soft-tissue contrast and real-time imaging capabilities of
                      MRI with the most conformal dose distribution and best dose
                      steering capability provided by modern PT. However, hybrid
                      systems for MR-integrated PT (MRiPT) have not been realized
                      so far due to a number of hitherto open technological
                      challenges. In recent years, various research groups have
                      started addressing these challenges and exploring the
                      technical feasibility and clinical potential of MRiPT. The
                      aim of this contribution is to review the different aspects
                      of MRiPT, to report on the status quo and to identify
                      important future research topics.Four aspects currently
                      under study and their future directions are discussed:
                      modelling and experimental investigations of electromagnetic
                      interactions between the MRI and PT systems, integration of
                      MRiPT workflows in clinical facilities, proton dose
                      calculation algorithms in magnetic fields, and MRI-only
                      based proton treatment planning approaches.Although MRiPT is
                      still in its infancy, significant progress on all four
                      aspects has been made, showing promising results that
                      justify further efforts for research and development to be
                      undertaken. First non-clinical research solutions have
                      recently been realized and are being thoroughly
                      characterized. The prospect that first prototype MRiPT
                      systems for clinical use will likely exist within the next 5
                      to 10 years seems realistic, but requires significant work
                      to be performed by collaborative efforts of research groups
                      and industrial partners.},
      subtyp        = {Review Article},
      cin          = {E041 / E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E041-20160331 / I:(DE-He78)E040-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32471500},
      pmc          = {pmc:PMC7260752},
      doi          = {10.1186/s13014-020-01571-x},
      url          = {https://inrepo02.dkfz.de/record/156956},
}