% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Weber:156972,
      author       = {J. Weber and C. J. Braun$^*$ and D. Saur$^*$ and R.
                      Rad$^*$},
      title        = {{I}n vivo functional screening for systems-level
                      integrative cancer genomics.},
      journal      = {Nature reviews / Cancer Cancer},
      volume       = {20},
      number       = {10},
      issn         = {1474-1768},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2020-01277},
      pages        = {573-593},
      year         = {2020},
      note         = {2020 Oct;20(10):573-593},
      abstract     = {With the genetic portraits of all major human malignancies
                      now available, we next face the challenge of characterizing
                      the function of mutated genes, their downstream targets,
                      interactions and molecular networks. Moreover, poorly
                      understood at the functional level are also non-mutated but
                      dysregulated genomes, epigenomes or transcriptomes.
                      Breakthroughs in manipulative mouse genetics offer new
                      opportunities to probe the interplay of molecules, cells and
                      systemic signals underlying disease pathogenesis in higher
                      organisms. Herein, we review functional screening strategies
                      in mice using genetic perturbation and chemical mutagenesis.
                      We outline the spectrum of genetic tools that exist, such as
                      transposons, CRISPR and RNAi and describe discoveries
                      emerging from their use. Genome-wide or targeted screens are
                      being used to uncover genomic and regulatory landscapes in
                      oncogenesis, metastasis or drug resistance. Versatile
                      screening systems support experimentation in diverse genetic
                      and spatio-temporal settings to integrate molecular,
                      cellular or environmental context-dependencies. We also
                      review the combination of in vivo screening and barcoding
                      strategies to study genetic interactions and quantitative
                      cancer dynamics during tumour evolution. These scalable
                      functional genomics approaches are transforming our ability
                      to interrogate complex biological systems.},
      subtyp        = {Review Article},
      cin          = {B062 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)MU01-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32636489},
      doi          = {10.1038/s41568-020-0275-9},
      url          = {https://inrepo02.dkfz.de/record/156972},
}