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| Home > Publications database > Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. > print |
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| 024 | 7 | _ | |a 10.1016/j.immuni.2020.05.001 |2 doi |
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| 100 | 1 | _ | |a Ni, Jing |0 P:(DE-He78)e6c151d449e1db05b1ffb5ad5ec656cf |b 0 |e First author |
| 245 | _ | _ | |a Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. |
| 260 | _ | _ | |a New York, NY |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Enhancing immune cell functions in tumors remains a major challenge in cancer immunotherapy. Hypoxia is a common feature of solid tumors, and cells adapt by upregulating the transcription factor HIF-1α. Here, we defined the transcriptional landscape of mouse tumor-infiltrating natural killer (NK) cells by using single-cell RNA sequencing. Conditional deletion of Hif1a in NK cells resulted in reduced tumor growth, elevated expression of activation markers, effector molecules, and an enriched NF-κB pathway in tumor-infiltrating NK cells. Interleukin-18 (IL-18) from myeloid cells was required for NF-κB activation and the enhanced anti-tumor activity of Hif1a-/- NK cells. Extended culture with an HIF-1α inhibitor increased human NK cell responses. Low HIF1A expression was associated with high expression of IFNG in human tumor-infiltrating NK cells, and an enriched NK-IL18-IFNG signature in solid tumors correlated with increased overall patient survival. Thus, inhibition of HIF-1α unleashes NK cell anti-tumor activity and could be exploited for cancer therapy. |
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| 700 | 1 | _ | |a Wang, Xi |0 P:(DE-He78)4759f8845c2e77163b9a1f0191a14821 |b 1 |e First author |
| 700 | 1 | _ | |a Stojanovic, Ana |0 P:(DE-He78)6459232320662d60ee842fd348128d87 |b 2 |e First author |
| 700 | 1 | _ | |a Zhang, Qin |0 P:(DE-He78)4cbe2c7f126a8fe4deb5c1b4d7cdc2ee |b 3 |
| 700 | 1 | _ | |a Wincher, Marian |b 4 |
| 700 | 1 | _ | |a Bühler, Lea Katharina |0 P:(DE-He78)491dd1552f3d82e92591b88eec8479aa |b 5 |
| 700 | 1 | _ | |a Arnold, Annette |0 P:(DE-He78)7c776439971ef21f36ac730cfbff7fff |b 6 |
| 700 | 1 | _ | |a Correia, Margareta P |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Winkler, Manuel |b 8 |
| 700 | 1 | _ | |a Koch, Philipp-Sebastian |b 9 |
| 700 | 1 | _ | |a Sexl, Veronika |b 10 |
| 700 | 1 | _ | |a Höfer, Thomas |0 P:(DE-He78)9dbe272aaadbdc810ab0bb291eae428e |b 11 |
| 700 | 1 | _ | |a Cerwenka, Adelheid |0 P:(DE-He78)d2b4dd8bdffe4aaa0f5e30e91587766f |b 12 |e Last author |
| 773 | _ | _ | |a 10.1016/j.immuni.2020.05.001 |g Vol. 52, no. 6, p. 1075 - 1087.e8 |0 PERI:(DE-600)2001966-X |n 6 |p 1075 - 1087.e8 |t Immunity |v 52 |y 2020 |x 1074-7613 |
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