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@ARTICLE{Zhu:157007,
      author       = {J. Zhu and X. Shu and X. Guo and D. Liu and J. Bao and R.
                      L. Milne and G. G. Giles and C. Wu and M. Du and E. White
                      and H. A. Risch and N. Malats and E. J. Duell and P. J.
                      Goodman and D. Li and P. Bracci and V. Katzke$^*$ and R. E.
                      Neale and S. Gallinger and S. K. Van Den Eeden and A. A.
                      Arslan and F. Canzian$^*$ and C. Kooperberg and L. E. Beane
                      Freeman and G. Scelo and K. Visvanathan and C. A. Haiman and
                      L. Le Marchand and H. Yu and G. M. Petersen and R.
                      Stolzenberg-Solomon and A. P. Klein and Q. Cai and J. Long
                      and X.-O. Shu and W. Zheng and L. Wu},
      title        = {{A}ssociations between {G}enetically {P}redicted {B}lood
                      {P}rotein {B}iomarkers and {P}ancreatic {C}ancer {R}isk.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {7},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-01304},
      pages        = {1501 - 1508},
      year         = {2020},
      abstract     = {Pancreatic ductal adenocarcinoma (PDAC) is one of the most
                      lethal malignancies, with few known risk factors and
                      biomarkers. Several blood protein biomarkers have been
                      linked to PDAC in previous studies, but these studies have
                      assessed only a limited number of biomarkers, usually in
                      small samples. In this study, we evaluated associations of
                      circulating protein levels and PDAC risk using genetic
                      instruments.To identify novel circulating protein biomarkers
                      of PDAC, we studied 8,280 cases and 6,728 controls of
                      European descent from the Pancreatic Cancer Cohort
                      Consortium and the Pancreatic Cancer Case-Control
                      Consortium, using genetic instruments of protein
                      quantitative trait loci.We observed associations between
                      predicted concentrations of 38 proteins and PDAC risk at an
                      FDR of < 0.05, including 23 of those proteins that showed an
                      association even after Bonferroni correction. These include
                      the protein encoded by ABO, which has been implicated as a
                      potential target gene of PDAC risk variant. Eight of the
                      identified proteins (LMA2L, TM11D, IP-10, ADH1B, STOM,
                      TENC1, DOCK9, and CRBB2) were associated with PDAC risk
                      after adjusting for previously reported PDAC risk variants
                      (OR ranged from 0.79 to 1.52). Pathway enrichment analysis
                      showed that the encoding genes for implicated proteins were
                      significantly enriched in cancer-related pathways, such as
                      STAT3 and IL15 production.We identified 38 candidates of
                      protein biomarkers for PDAC risk.This study identifies novel
                      protein biomarker candidates for PDAC, which if validated by
                      additional studies, may contribute to the etiologic
                      understanding of PDAC development.},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32439797},
      pmc          = {pmc:PMC7334065},
      doi          = {10.1158/1055-9965.EPI-20-0091},
      url          = {https://inrepo02.dkfz.de/record/157007},
}