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@ARTICLE{Delacher:157014,
      author       = {M. Delacher$^*$ and M. M. Barra$^*$ and Y. Herzig and K.
                      Eichelbaum and M.-R. Rafiee and D. M. Richards$^*$ and U.
                      Träger$^*$ and A.-C. Hofer$^*$ and A. Kazakov$^*$ and K.
                      Braband$^*$ and M. Gonzalez$^*$ and L. Wöhrl and K.
                      Schambeck and C. D. Imbusch$^*$ and J. Abramson and J.
                      Krijgsveld$^*$ and M. Feuerer$^*$},
      title        = {{Q}uantitative {P}roteomics {I}dentifies {TCF}1 as a
                      {N}egative {R}egulator of {F}oxp3 {E}xpression in
                      {C}onventional {T} {C}ells.},
      journal      = {iScience},
      volume       = {23},
      number       = {5},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01311},
      pages        = {101127},
      year         = {2020},
      note         = {#EA:D100#LA:D100#},
      abstract     = {Regulatory T cells are important regulators of the immune
                      system and have versatile functions for the homeostasis and
                      repair of tissues. They express the forkhead box
                      transcription factor Foxp3 as a lineage-defining protein.
                      Negative regulators of Foxp3 expression are not well
                      understood. Here, we generated double-stranded DNA probes
                      complementary to the Foxp3 promoter sequence and performed a
                      pull-down with nuclear protein in vitro, followed by
                      elution of bound proteins and quantitative mass
                      spectrometry. Of the Foxp3-promoter-binding transcription
                      factors identified with this approach, one was T cell
                      factor 1 (TCF1). Using viral over-expression, we identified
                      TCF1 as a repressor of Foxp3 expression. In TCF1-deficient
                      animals, increased levels of Foxp3intermediateCD25negative
                      T cells were identified. CRISPR-Cas9 knockout studies in
                      primary human and mouse conventional CD4 T (Tconv) cells
                      revealed that TCF1 protects Tconv cells from inadvertent
                      Foxp3 expression. Our data implicate a role of TCF1 in
                      suppressing Foxp3 expression in activated T cells.},
      cin          = {D100 / B330 / B230},
      ddc          = {050},
      cid          = {I:(DE-He78)D100-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)B230-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32422593},
      pmc          = {pmc:PMC7229326},
      doi          = {10.1016/j.isci.2020.101127},
      url          = {https://inrepo02.dkfz.de/record/157014},
}