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| 001 | 157014 | ||
| 005 | 20240229123126.0 | ||
| 024 | 7 | _ | |a 10.1016/j.isci.2020.101127 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 050 |
| 100 | 1 | _ | |a Delacher, Michael |0 P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09 |b 0 |e First author |
| 245 | _ | _ | |a Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells. |
| 260 | _ | _ | |a St. Louis |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1603097291_18936 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:D100#LA:D100# |
| 520 | _ | _ | |a Regulatory T cells are important regulators of the immune system and have versatile functions for the homeostasis and repair of tissues. They express the forkhead box transcription factor Foxp3 as a lineage-defining protein. Negative regulators of Foxp3 expression are not well understood. Here, we generated double-stranded DNA probes complementary to the Foxp3 promoter sequence and performed a pull-down with nuclear protein in vitro, followed by elution of bound proteins and quantitative mass spectrometry. Of the Foxp3-promoter-binding transcription factors identified with this approach, one was T cell factor 1 (TCF1). Using viral over-expression, we identified TCF1 as a repressor of Foxp3 expression. In TCF1-deficient animals, increased levels of Foxp3intermediateCD25negative T cells were identified. CRISPR-Cas9 knockout studies in primary human and mouse conventional CD4 T (Tconv) cells revealed that TCF1 protects Tconv cells from inadvertent Foxp3 expression. Our data implicate a role of TCF1 in suppressing Foxp3 expression in activated T cells. |
| 536 | _ | _ | |a 314 - Tumor immunology (POF3-314) |0 G:(DE-HGF)POF3-314 |c POF3-314 |f POF III |x 0 |
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| 700 | 1 | _ | |a Herzig, Yonatan |b 2 |
| 700 | 1 | _ | |a Eichelbaum, Katrin |b 3 |
| 700 | 1 | _ | |a Rafiee, Mahmoud-Reza |b 4 |
| 700 | 1 | _ | |a Richards, David M |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Träger, Ulrike |0 P:(DE-He78)4d320583e7adaedcb8374d787eb6bfe5 |b 6 |
| 700 | 1 | _ | |a Hofer, Ann-Cathrin |0 P:(DE-He78)24f65e08387eafe8f511b710e366fdf4 |b 7 |
| 700 | 1 | _ | |a Kazakov, Alexander |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Braband, Kathrin |0 P:(DE-He78)48a0f3d6278cc8d51ce937ca7db9dba8 |b 9 |
| 700 | 1 | _ | |a Gonzalez, Marina |0 P:(DE-HGF)0 |b 10 |
| 700 | 1 | _ | |a Wöhrl, Lukas |b 11 |
| 700 | 1 | _ | |a Schambeck, Kathrin |b 12 |
| 700 | 1 | _ | |a Imbusch, Charles D |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Abramson, Jakub |b 14 |
| 700 | 1 | _ | |a Krijgsveld, Jeroen |0 P:(DE-He78)939d5891259c638c1ab053b1456a578c |b 15 |
| 700 | 1 | _ | |a Feuerer, Markus |0 P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f |b 16 |e Last author |
| 773 | _ | _ | |a 10.1016/j.isci.2020.101127 |g Vol. 23, no. 5, p. 101127 - |0 PERI:(DE-600)2927064-9 |n 5 |p 101127 |t iScience |v 23 |y 2020 |x 2589-0042 |
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