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@ARTICLE{Bostel:157056,
      author       = {T. Bostel$^*$ and C. Dreher$^*$ and D. Wollschläger and A.
                      Mayer and F. König$^*$ and S. Bickelhaupt$^*$ and H. P.
                      Schlemmer$^*$ and P. E. Huber$^*$ and F. Sterzing$^*$ and P.
                      Bäumer$^*$ and J. Debus$^*$ and N. H. Nicolay$^*$},
      title        = {{E}xploring {MR} regression patterns in rectal cancer
                      during neoadjuvant radiochemotherapy with daily {T}2- and
                      diffusion-weighted {MRI}.},
      journal      = {Radiation oncology},
      volume       = {15},
      number       = {1},
      issn         = {1748-717X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2020-01347},
      pages        = {171},
      year         = {2020},
      note         = {#EA:E050#LA:E050#},
      abstract     = {To date, only limited magnetic resonance imaging (MRI) data
                      are available concerning tumor regression during neoadjuvant
                      radiochemotherapy (RCT) of rectal cancer patients, which is
                      a prerequisite for adaptive radiotherapy (RT) concepts. This
                      exploratory study prospectively evaluated daily fractional
                      MRI during neoadjuvant treatment to analyze the predictive
                      value of MR biomarkers for treatment response.Locally
                      advanced rectal cancer patients were examined with daily MRI
                      during neoadjuvant RCT. Contouring of the tumor volume was
                      performed for each MRI scan by using T2- and
                      diffusion-weighted-imaging (DWI)-sequences. The daily
                      apparent-diffusion coefficient (ADC) was calculated.
                      Volumetric and functional tumor changes during RCT were
                      analyzed and correlated with the pathological response after
                      surgical resection.In total, 171 MRI scans of eight patients
                      were analyzed regarding anatomical and functional dynamics
                      during RCT. Pathological complete response (pCR) could be
                      achieved in four patients, and four patients had a
                      pathological partial response (pPR) following neoadjuvant
                      treatment. T2- and DWI-based volumetry proved to be
                      statistically significant in terms of therapeutic response,
                      and volumetric thresholds at week two and week four during
                      RCT were defined for the prediction of pCR. In contrast, the
                      average tumor ADC values widely overlapped between both
                      response groups during RCT and appeared inadequate to
                      predict treatment response in our patient cohort.This
                      prospective exploratory study supports the hypothesis that
                      MRI may be able to predict pCR of rectal cancers early
                      during neoadjuvant RCT. Our data therefore provide a useful
                      template to tailor future MR-guided adaptive treatment
                      concepts.},
      cin          = {E050 / E055 / E010 / E250},
      ddc          = {610},
      cid          = {I:(DE-He78)E050-20160331 / I:(DE-He78)E055-20160331 /
                      I:(DE-He78)E010-20160331 / I:(DE-He78)E250-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32653003},
      doi          = {10.1186/s13014-020-01613-4},
      url          = {https://inrepo02.dkfz.de/record/157056},
}