TY  - JOUR
AU  - Karunamuni, Roshan A
AU  - Huynh-Le, Minh-Phuong
AU  - Fan, Chun C
AU  - Eeles, Rosalind A
AU  - Easton, Douglas F
AU  - Kote-Jarai, ZSofia
AU  - Amin Al Olama, Ali
AU  - Benlloch Garcia, Sara
AU  - Muir, Kenneth
AU  - Gronberg, Henrik
AU  - Wiklund, Fredrik
AU  - Aly, Markus
AU  - Schleutker, Johanna
AU  - Sipeky, Csilla
AU  - Tammela, Teuvo L J
AU  - Nordestgaard, Børge G
AU  - Key, Tim J
AU  - Travis, Ruth C
AU  - Neal, David E
AU  - Donovan, Jenny L
AU  - Hamdy, Freddie C
AU  - Pharoah, Paul
AU  - Pashayan, Nora
AU  - Khaw, Kay-Tee
AU  - Thibodeau, Stephen N
AU  - McDonnell, Shannon K
AU  - Schaid, Daniel J
AU  - Maier, Christiane
AU  - Vogel, Walther
AU  - Luedeke, Manuel
AU  - Herkommer, Kathleen
AU  - Kibel, Adam S
AU  - Cybulski, Cezary
AU  - Wokolorczyk, Dominika
AU  - Kluzniak, Wojciech
AU  - Cannon-Albright, Lisa
AU  - Brenner, Hermann
AU  - Schöttker, Ben
AU  - Holleczek, Bernd
AU  - Park, Jong Y
AU  - Sellers, Thomas A
AU  - Lin, Hui-Yi
AU  - Slavov, Chavdar
AU  - Kaneva, Radka
AU  - Mitev, Vanio
AU  - Batra, Jyotsna
AU  - Clements, Judith A
AU  - Spurdle, Amanda
AU  - Teixeira, Manuel R
AU  - Paulo, Paula
AU  - Maia, Sofia
AU  - Pandha, Hardev
AU  - Michael, Agnieszka
AU  - Mills, Ian G
AU  - Andreassen, Ole A
AU  - Dale, Anders M
AU  - Seibert, Tyler M
TI  - The effect of sample size on polygenic hazard models for prostate cancer.
JO  - European journal of human genetics
VL  - 28
IS  - 10
SN  - 1476-5438
CY  - Basingstoke
PB  - Stockton Press
M1  - DKFZ-2020-01361
SP  - 1467-1475
PY  - 2020
N1  - 2020 Oct;28(10):1467-1475
AB  - We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium. The dataset included 201,590 SNPs per subject, and was split into training and testing sets. Established-SNP models considered 65 SNPs that had been previously associated with prostate cancer. Discovery-SNP models used stepwise selection to identify new SNPs. The performance of each PHS model was calculated for random sizes of the training set. The performance of a representative Established-SNP model was estimated for random sizes of the testing set. Mean HR98/50 (hazard ratio of top 2
LB  - PUB:(DE-HGF)16
C6  - pmid:32514134
DO  - DOI:10.1038/s41431-020-0664-2
UR  - https://inrepo02.dkfz.de/record/157070
ER  -