TY  - JOUR
AU  - Hardikar, Sheetal
AU  - Albrechtsen, Richard D
AU  - Achaintre, David
AU  - Lin, Tengda
AU  - Pauleck, Svenja
AU  - Playdon, Mary
AU  - Holowatyj, Andreana N
AU  - Gigic, Biljana
AU  - Schrotz-King, Petra
AU  - Boehm, Juergen
AU  - Habermann, Nina
AU  - Brezina, Stefanie
AU  - Gsur, Andrea
AU  - van Roekel, Eline H
AU  - Weijenberg, Matty P
AU  - Keski-Rahkonen, Pekka
AU  - Scalbert, Augustin
AU  - Ose, Jennifer
AU  - Ulrich, Cornelia M
TI  - Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles.
JO  - Metabolites
VL  - 10
IS  - 5
SN  - 2218-1989
CY  - Basel
PB  - MDPI
M1  - DKFZ-2020-01365
SP  - 213 
PY  - 2020
AB  - Demographic, lifestyle and biospecimen-related factors at the time of blood collection can influence metabolite levels in epidemiological studies. Identifying the major influences on metabolite concentrations is critical to designing appropriate sample collection protocols and considering covariate adjustment in metabolomics analyses. We examined the association of age, sex, and other short-term pre-blood collection factors (time of day, season, fasting duration, physical activity, NSAID use, smoking and alcohol consumption in the days prior to collection) with 133 targeted plasma metabolites (acylcarnitines, amino acids, biogenic amines, sphingolipids, glycerophospholipids, and hexoses) among 108 individuals that reported exposures within 48 h before collection. The differences in mean metabolite concentrations were assessed between groups based on pre-collection factors using two-sided t-tests and ANOVA with FDR correction. Percent differences in metabolite concentrations were negligible across season, time of day of collection, fasting status or lifestyle behaviors at the time of collection, including physical activity or the use of tobacco, alcohol or NSAIDs. The metabolites differed in concentration between the age and sex categories for 21.8
LB  - PUB:(DE-HGF)16
C6  - pmid:32455751
C2  - pmc:PMC7281389
DO  - DOI:10.3390/metabo10050213
UR  - https://inrepo02.dkfz.de/record/157074
ER  -