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@ARTICLE{Eyl:157085,
      author       = {R. E. Eyl$^*$ and M. S. Y. Thong$^*$ and P. R. Carr$^*$ and
                      L. Jansen$^*$ and L. Koch-Gallenkamp$^*$ and M.
                      Hoffmeister$^*$ and J. Chang-Claude$^*$ and H. Brenner$^*$
                      and V. Arndt$^*$},
      title        = {{P}hysical activity and long-term fatigue among colorectal
                      cancer survivors - a population-based prospective study.},
      journal      = {BMC cancer},
      volume       = {20},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-01376},
      pages        = {438},
      year         = {2020},
      note         = {#EA:C070#LA:C071#},
      abstract     = {Evidence suggests that physical activity (PA) is beneficial
                      for reducing fatigue in colorectal cancer (CRC) survivors.
                      However, little is known regarding long-term effects of PA
                      on fatigue and whether pre-diagnosis PA is associated with
                      less fatigue in the years after diagnosis. Our study aimed
                      to investigate the association of pre- and post-diagnosis PA
                      with long-term fatigue in CRC survivors.This study used a
                      German population-based cohort of 1781 individuals,
                      diagnosed with CRC in 2003-2014, and alive at five-year
                      follow-up (5YFU). Physical activity was assessed at
                      diagnosis and at 5YFU. Fatigue was assessed by the Fatigue
                      Assessment Questionnaire and the EORTC Quality of Life
                      Questionnaire-Core 30 fatigue subscale at 5YFU.
                      Multivariable linear regression was used to explore
                      associations between pre- and post-diagnosis PA and fatigue
                      at 5YFU.No evidence was found that pre-diagnosis PA was
                      associated with less fatigue in long-term CRC survivors.
                      Pre-diagnosis work-related PA and vigorous PA were even
                      associated with higher levels of physical (Beta
                      (ß) = 2.52, $95\%$ confidence interval
                      (CI) = 1.14-3.90; ß = 2.03, CI = 0.65-3.41),
                      cognitive (ß = 0.17, CI = 0.05-0.28; ß = 0.13,
                      CI = 0.01-0.25), and affective fatigue (ß = 0.26,
                      CI = 0.07-0.46; ß = 0.21, CI = 0.02-0.40). In
                      cross-sectional analyses, post-diagnosis PA was strongly
                      associated with lower fatigue on all scales.In this study,
                      pre-diagnosis PA does not appear to be associated with less
                      fatigue among long-term CRC survivors. Our results support
                      the importance of ongoing PA in long-term CRC survivors. Our
                      findings might be used as a basis for further research on
                      specific PA interventions to improve the long-term outcome
                      of CRC survivors.},
      cin          = {C070 / C071 / HD01 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C071-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32423448},
      pmc          = {pmc:PMC7236466},
      doi          = {10.1186/s12885-020-06918-x},
      url          = {https://inrepo02.dkfz.de/record/157085},
}