TY  - JOUR
AU  - Went, Molly
AU  - Cornish, Alex J
AU  - Law, Philip J
AU  - Kinnersley, Ben
AU  - van Duin, Mark
AU  - Weinhold, Niels
AU  - Försti, Asta
AU  - Hansson, Markus
AU  - Sonneveld, Pieter
AU  - Goldschmidt, Hartmut
AU  - Morgan, Gareth J
AU  - Hemminki, Kari
AU  - Nilsson, Björn
AU  - Kaiser, Martin
AU  - Houlston, Richard S
TI  - Search for multiple myeloma risk factors using Mendelian randomization.
JO  - Blood advances
VL  - 4
IS  - 10
SN  - 2473-9537
CY  - Washington, DC
PB  - American Society of Hematology
M1  - DKFZ-2020-01381
SP  - 2172 - 2179
PY  - 2020
AB  - The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study (PheWAS) to search for factors influencing MM risk. We performed an MR-PheWAS analyzing 249 phenotypes, proxied by 10 225 genetic variants, and summary genetic data from a GWAS of 7717 MM cases and 29 304 controls. Odds ratios (ORs) per 1 standard deviation increase in each phenotype were estimated under an inverse variance weighted random effects model. A Bonferroni-corrected threshold of P = 2 × 10-4 was considered significant, whereas P < .05 was considered suggestive of an association. Although no significant associations with MM risk were observed among the 249 phenotypes, 28 phenotypes showed evidence suggestive of association, including increased levels of serum vitamin B6 and blood carnitine (P = 1.1 × 10-3) with greater MM risk and ω-3 fatty acids (P = 5.4 × 10-4) with reduced MM risk. A suggestive association between increased telomere length and reduced MM risk was also noted; however, this association was primarily driven by the previously identified risk variant rs10936599 at 3q26 (TERC). Although not statistically significant, increased body mass index was associated with increased risk (OR, 1.10; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:32433745
C2  - pmc:PMC7252541
DO  - DOI:10.1182/bloodadvances.2020001502
UR  - https://inrepo02.dkfz.de/record/157090
ER  -