%0 Journal Article
%A Blunk, Inga
%A Thomsen, Hauke
%A Reinsch, Norbert
%A Mayer, Manfred
%A Försti, Asta
%A Sundquist, Jan
%A Sundquist, Kristina
%A Hemminki, Kari
%T Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.
%J Scientific reports
%V 10
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2020-01425
%P 11562
%D 2020
%Z #LA:C050#
%X Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32665606
%R 10.1038/s41598-020-68212-x
%U https://inrepo02.dkfz.de/record/157139