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000157139 1001_ $$aBlunk, Inga$$b0
000157139 245__ $$aGenomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.
000157139 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2020
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000157139 520__ $$aImprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00% (± 2.00%) and 15.00% (± 6.00%) of the phenotypic variance, the maternal environmental variance was significant for T1D (P = 1.60 × 10-24) and for RA (P = 0.02). For the first time, the existence of maternal genetic effects on RA was indicated, contributing up to 16.00% (± 3.00%) of the total variance. Environmental factors such as the social economic index, the number of offspring, birth year as well as their interactions with sex showed large effects.
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000157139 7001_ $$0P:(DE-He78)9af7dea9c075a972fcfa22b583471dae$$aThomsen, Hauke$$b1
000157139 7001_ $$aReinsch, Norbert$$b2
000157139 7001_ $$aMayer, Manfred$$b3
000157139 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b4$$udkfz
000157139 7001_ $$aSundquist, Jan$$b5
000157139 7001_ $$aSundquist, Kristina$$b6
000157139 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b7$$eLast author$$udkfz
000157139 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-020-68212-x$$gVol. 10, no. 1, p. 11562$$n1$$p11562$$tScientific reports$$v10$$x2045-2322$$y2020
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