TY  - JOUR
AU  - Blunk, Inga
AU  - Thomsen, Hauke
AU  - Reinsch, Norbert
AU  - Mayer, Manfred
AU  - Försti, Asta
AU  - Sundquist, Jan
AU  - Sundquist, Kristina
AU  - Hemminki, Kari
TI  - Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.
JO  - Scientific reports
VL  - 10
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2020-01425
SP  - 11562
PY  - 2020
N1  - #LA:C050#
AB  - Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may also play a role. By using a mixed model that is able to simultaneously consider all kinds of POEs, the importance of POEs for the development of T1D and RA was investigated in a variance components analysis. The analysis was based on Swedish population-scale pedigree data. With P = 0.18 (T1D) and P = 0.26 (RA) imprinting variances were not significant. Explaining up to 19.00
LB  - PUB:(DE-HGF)16
C6  - pmid:32665606
DO  - DOI:10.1038/s41598-020-68212-x
UR  - https://inrepo02.dkfz.de/record/157139
ER  -