% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Blunk:157139,
      author       = {I. Blunk and H. Thomsen$^*$ and N. Reinsch and M. Mayer and
                      A. Försti$^*$ and J. Sundquist and K. Sundquist and K.
                      Hemminki$^*$},
      title        = {{G}enomic imprinting analyses identify maternal effects as
                      a cause of phenotypic variability in type 1 diabetes and
                      rheumatoid arthritis.},
      journal      = {Scientific reports},
      volume       = {10},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-01425},
      pages        = {11562},
      year         = {2020},
      note         = {#LA:C050#},
      abstract     = {Imprinted genes, giving rise to parent-of-origin effects
                      (POEs), have been hypothesised to affect type 1 diabetes
                      (T1D) and rheumatoid arthritis (RA). However, maternal
                      effects may also play a role. By using a mixed model that is
                      able to simultaneously consider all kinds of POEs, the
                      importance of POEs for the development of T1D and RA was
                      investigated in a variance components analysis. The analysis
                      was based on Swedish population-scale pedigree data. With
                      P = 0.18 (T1D) and P = 0.26 (RA) imprinting
                      variances were not significant. Explaining up to $19.00\%$
                      $(± 2.00\%)$ and $15.00\%$ $(± 6.00\%)$ of the
                      phenotypic variance, the maternal environmental variance was
                      significant for T1D (P = 1.60 × 10-24) and for RA
                      (P = 0.02). For the first time, the existence of
                      maternal genetic effects on RA was indicated, contributing
                      up to $16.00\%$ $(± 3.00\%)$ of the total variance.
                      Environmental factors such as the social economic index, the
                      number of offspring, birth year as well as their
                      interactions with sex showed large effects.},
      cin          = {C050 / B062 / HD01},
      ddc          = {600},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32665606},
      doi          = {10.1038/s41598-020-68212-x},
      url          = {https://inrepo02.dkfz.de/record/157139},
}