TY  - JOUR
AU  - Tschirdewahn, Stephan
AU  - Wiesenfarth, Manuel
AU  - Bonekamp, David
AU  - Püllen, Lukas
AU  - Reis, Henning
AU  - Panic, Andrej
AU  - Kesch, Claudia
AU  - Darr, Christopher
AU  - Heß, Jochen
AU  - Giganti, Francesco
AU  - Moore, Caroline M
AU  - Guberina, Nika
AU  - Forsting, Michael
AU  - Wetter, Axel
AU  - Hadaschik, Boris
AU  - Radtke, Jan Philipp
TI  - Detection of Significant Prostate Cancer Using Target Saturation in Transperineal Magnetic Resonance Imaging/Transrectal Ultrasonography-fusion Biopsy.
JO  - European urology focus
VL  - 7
IS  - 6
SN  - 2405-4569
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2020-01429
SP  - 1300-1307
PY  - 2021
N1  - 2021 Nov;7(6):1300-1307
AB  - Multiparametric magnetic resonance imaging (mpMRI) and targeted biopsies (TBs) facilitate accurate detection of significant prostate cancer (sPC). However, it remains unclear how many cores should be applied per target.To assess sPC detection rates of two different target-dependent magnetic resonance imaging (MRI)/transrectal ultrasonography (TRUS)-fusion biopsy approaches (TB and target saturation [TS]) compared with extended systematic biopsies (SBs).Retrospective single-centre outcome of transperineal MRI/TRUS-fusion biopsies of 213 men was evaluated. All men underwent TB with a median of four cores per MRI lesion, followed by a median of 24 SBs, performed by experienced urologists. Cancer and sPC (International Society of Urological Pathology grade group ≥2) detection rates were analysed. TB was compared with SB and TS, with nine cores per target, calculated by the Ginsburg scheme and using individual cores of the lesion and its 'penumbra'.Cancer detection rates were calculated for TS, TB, and SB at both lesion and patient level. Combination of SB + TB served as a reference. Statistical differences in prostate cancer (PC) detection between groups were calculated using McNemar's tests with confidence intervals.TS detected 99
LB  - PUB:(DE-HGF)16
C6  - pmid:32660838
DO  - DOI:10.1016/j.euf.2020.06.020
UR  - https://inrepo02.dkfz.de/record/157143
ER  -