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@ARTICLE{Tschirdewahn:157143,
      author       = {S. Tschirdewahn and M. Wiesenfarth$^*$ and D. Bonekamp$^*$
                      and L. Püllen and H. Reis and A. Panic and C. Kesch and C.
                      Darr and J. Heß and F. Giganti and C. M. Moore and N.
                      Guberina and M. Forsting and A. Wetter and B. Hadaschik and
                      J. P. Radtke$^*$},
      title        = {{D}etection of {S}ignificant {P}rostate {C}ancer {U}sing
                      {T}arget {S}aturation in {T}ransperineal {M}agnetic
                      {R}esonance {I}maging/{T}ransrectal {U}ltrasonography-fusion
                      {B}iopsy.},
      journal      = {European urology focus},
      volume       = {7},
      number       = {6},
      issn         = {2405-4569},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01429},
      pages        = {1300-1307},
      year         = {2021},
      note         = {2021 Nov;7(6):1300-1307},
      abstract     = {Multiparametric magnetic resonance imaging (mpMRI) and
                      targeted biopsies (TBs) facilitate accurate detection of
                      significant prostate cancer (sPC). However, it remains
                      unclear how many cores should be applied per target.To
                      assess sPC detection rates of two different target-dependent
                      magnetic resonance imaging (MRI)/transrectal ultrasonography
                      (TRUS)-fusion biopsy approaches (TB and target saturation
                      [TS]) compared with extended systematic biopsies
                      (SBs).Retrospective single-centre outcome of transperineal
                      MRI/TRUS-fusion biopsies of 213 men was evaluated. All men
                      underwent TB with a median of four cores per MRI lesion,
                      followed by a median of 24 SBs, performed by experienced
                      urologists. Cancer and sPC (International Society of
                      Urological Pathology grade group ≥2) detection rates were
                      analysed. TB was compared with SB and TS, with nine cores
                      per target, calculated by the Ginsburg scheme and using
                      individual cores of the lesion and its 'penumbra'.Cancer
                      detection rates were calculated for TS, TB, and SB at both
                      lesion and patient level. Combination of SB + TB served as a
                      reference. Statistical differences in prostate cancer (PC)
                      detection between groups were calculated using McNemar's
                      tests with confidence intervals.TS detected $99\%$ of 134
                      sPC lesions, which was significantly higher than the
                      detection by TB $(87\%,$ p = 0.001) and SB $(82\%,$ p <
                      0.001). SB detected significantly more of the 72 low-risk PC
                      lesions than TB $(99\%$ vs $68\%,$ p < 0.001) and $10\%$ (p
                      = 0.15) more than that detected by TS. At a per-patient
                      level, $99\%$ of men harbouring sPC were detected by TS.
                      This was significantly higher than that by TB and SB
                      $(89\%,$ p = 0.03 and $81\%,$ p = 0.001, respectively).
                      Limitations include limited generalisability, as a
                      transperineal biopsy route was used.TS detected
                      significantly more cases of sPC than TB and extended SB.
                      Given that both $99\%$ of sPC lesions and men harbouring sPC
                      were identified by TS, the results suggest that this
                      approach allows to omit SB cores without compromising sPC
                      detection.Target saturation of magnetic resonance
                      imaging-suspicious prostate lesions provides excellent
                      cancer detection and finds fewer low-risk tumours than the
                      current gold standard combination of targeted and systematic
                      biopsies.},
      cin          = {C060 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32660838},
      doi          = {10.1016/j.euf.2020.06.020},
      url          = {https://inrepo02.dkfz.de/record/157143},
}