%0 Journal Article
%A Heisser, Thomas
%A Weigl, Korbinian
%A Hoffmeister, Michael
%A Brenner, Hermann
%T Age-specific sequence of colorectal cancer screening options in Germany: A model-based critical evaluation.
%J PLoS medicine
%V 17
%N 7
%@ 1549-1676
%C Lawrence, Kan.
%I PLoS
%M DKFZ-2020-01443
%P e1003194 -
%D 2020
%Z #EA:C070#LA:C070#
%X The current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implications of this approach for key parameters of diagnostic performance.Using a multistate Markov model, we estimated the expected detection rates of advanced neoplasms (advanced adenomas and cancers) and number needed to scope (NNS) to detect 1 advanced neoplasm at a first screening colonoscopy conducted at age 55 after 5 preceding negative FITs and compared them with the corresponding estimates for a first screening colonoscopy at age 55 with no preceding FIT testing. In individuals with 5 consecutive negative FITs undergoing screening colonoscopy at age 55, expected colonoscopy detection rate (NNS) was 3.7
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32678831
%R 10.1371/journal.pmed.1003194
%U https://inrepo02.dkfz.de/record/157163