000157163 001__ 157163
000157163 005__ 20240229123130.0
000157163 0247_ $$2doi$$a10.1371/journal.pmed.1003194
000157163 0247_ $$2pmid$$apmid:32678831
000157163 0247_ $$2ISSN$$a1549-1277
000157163 0247_ $$2ISSN$$a1549-1676
000157163 0247_ $$2altmetric$$aaltmetric:85998156
000157163 037__ $$aDKFZ-2020-01443
000157163 041__ $$aeng
000157163 082__ $$a610
000157163 1001_ $$00000-0002-1348-3350$$aHeisser, Thomas$$b0$$eFirst author
000157163 245__ $$aAge-specific sequence of colorectal cancer screening options in Germany: A model-based critical evaluation.
000157163 260__ $$aLawrence, Kan.$$bPLoS$$c2020
000157163 3367_ $$2DRIVER$$aarticle
000157163 3367_ $$2DataCite$$aOutput Types/Journal article
000157163 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1603096424_18443
000157163 3367_ $$2BibTeX$$aARTICLE
000157163 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000157163 3367_ $$00$$2EndNote$$aJournal Article
000157163 500__ $$a#EA:C070#LA:C070#
000157163 520__ $$aThe current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implications of this approach for key parameters of diagnostic performance.Using a multistate Markov model, we estimated the expected detection rates of advanced neoplasms (advanced adenomas and cancers) and number needed to scope (NNS) to detect 1 advanced neoplasm at a first screening colonoscopy conducted at age 55 after 5 preceding negative FITs and compared them with the corresponding estimates for a first screening colonoscopy at age 55 with no preceding FIT testing. In individuals with 5 consecutive negative FITs undergoing screening colonoscopy at age 55, expected colonoscopy detection rate (NNS) was 3.7% (27) and 0.10% (1,021) for any advanced neoplasm and cancer, respectively, in men, and 2.1% (47) and 0.05% (1,880) for any advanced neoplasm and cancer, respectively, in women. These NNS values for detecting 1 advanced neoplasm are approximately 3-fold higher, and the NNS values for detecting 1 cancer are approximately 8-fold higher, than those for a first screening colonoscopy at age 55 without prior FITs. This study is limited by model simplifying assumptions and uncertainties related to input parameters.Screening colonoscopy at age 55 after 5 consecutive negative FITs at ages 50-54, as currently offered in the German cancer early detection program, is expected to have very low positive predictive value. Our results may inform efforts to enhance the design of screening programs.
000157163 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000157163 588__ $$aDataset connected to CrossRef, PubMed,
000157163 7001_ $$0P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aWeigl, Korbinian$$b1
000157163 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b2
000157163 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b3$$eLast author
000157163 773__ $$0PERI:(DE-600)2164823-2$$a10.1371/journal.pmed.1003194$$gVol. 17, no. 7, p. e1003194 -$$n7$$pe1003194 -$$tPLoS medicine$$v17$$x1549-1676$$y2020
000157163 909CO $$ooai:inrepo02.dkfz.de:157163$$pVDB
000157163 9101_ $$0I:(DE-588b)2036810-0$$60000-0002-1348-3350$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000157163 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000157163 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000157163 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000157163 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000157163 9141_ $$y2020
000157163 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLOS MED : 2018$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2020-02-27
000157163 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bPLOS MED : 2018$$d2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$f2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$f2020-02-27
000157163 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-02-27
000157163 9202_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000157163 9200_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000157163 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000157163 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x1
000157163 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x2
000157163 980__ $$ajournal
000157163 980__ $$aVDB
000157163 980__ $$aI:(DE-He78)C070-20160331
000157163 980__ $$aI:(DE-He78)HD01-20160331
000157163 980__ $$aI:(DE-He78)C120-20160331
000157163 980__ $$aUNRESTRICTED