TY  - JOUR
AU  - Heisser, Thomas
AU  - Weigl, Korbinian
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Age-specific sequence of colorectal cancer screening options in Germany: A model-based critical evaluation.
JO  - PLoS medicine
VL  - 17
IS  - 7
SN  - 1549-1676
CY  - Lawrence, Kan.
PB  - PLoS
M1  - DKFZ-2020-01443
SP  - e1003194 -
PY  - 2020
N1  - #EA:C070#LA:C070#
AB  - The current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implications of this approach for key parameters of diagnostic performance.Using a multistate Markov model, we estimated the expected detection rates of advanced neoplasms (advanced adenomas and cancers) and number needed to scope (NNS) to detect 1 advanced neoplasm at a first screening colonoscopy conducted at age 55 after 5 preceding negative FITs and compared them with the corresponding estimates for a first screening colonoscopy at age 55 with no preceding FIT testing. In individuals with 5 consecutive negative FITs undergoing screening colonoscopy at age 55, expected colonoscopy detection rate (NNS) was 3.7
LB  - PUB:(DE-HGF)16
C6  - pmid:32678831
DO  - DOI:10.1371/journal.pmed.1003194
UR  - https://inrepo02.dkfz.de/record/157163
ER  -