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| 001 | 157163 | ||
| 005 | 20240229123130.0 | ||
| 024 | 7 | _ | |a 10.1371/journal.pmed.1003194 |2 doi |
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Heisser, Thomas |0 0000-0002-1348-3350 |b 0 |e First author |
| 245 | _ | _ | |a Age-specific sequence of colorectal cancer screening options in Germany: A model-based critical evaluation. |
| 260 | _ | _ | |a Lawrence, Kan. |c 2020 |b PLoS |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a #EA:C070#LA:C070# |
| 520 | _ | _ | |a The current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implications of this approach for key parameters of diagnostic performance.Using a multistate Markov model, we estimated the expected detection rates of advanced neoplasms (advanced adenomas and cancers) and number needed to scope (NNS) to detect 1 advanced neoplasm at a first screening colonoscopy conducted at age 55 after 5 preceding negative FITs and compared them with the corresponding estimates for a first screening colonoscopy at age 55 with no preceding FIT testing. In individuals with 5 consecutive negative FITs undergoing screening colonoscopy at age 55, expected colonoscopy detection rate (NNS) was 3.7% (27) and 0.10% (1,021) for any advanced neoplasm and cancer, respectively, in men, and 2.1% (47) and 0.05% (1,880) for any advanced neoplasm and cancer, respectively, in women. These NNS values for detecting 1 advanced neoplasm are approximately 3-fold higher, and the NNS values for detecting 1 cancer are approximately 8-fold higher, than those for a first screening colonoscopy at age 55 without prior FITs. This study is limited by model simplifying assumptions and uncertainties related to input parameters.Screening colonoscopy at age 55 after 5 consecutive negative FITs at ages 50-54, as currently offered in the German cancer early detection program, is expected to have very low positive predictive value. Our results may inform efforts to enhance the design of screening programs. |
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| 700 | 1 | _ | |a Weigl, Korbinian |0 P:(DE-He78)f4e98340e600f7411886c21c7b778d36 |b 1 |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 2 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |e Last author |
| 773 | _ | _ | |a 10.1371/journal.pmed.1003194 |g Vol. 17, no. 7, p. e1003194 - |0 PERI:(DE-600)2164823-2 |n 7 |p e1003194 - |t PLoS medicine |v 17 |y 2020 |x 1549-1676 |
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