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@ARTICLE{Nguyen:157213,
      author       = {M. T. N. Nguyen$^*$ and D. C. Laetsch$^*$ and L.-J.
                      Chen$^*$ and W. E. Haefeli and A. D. Meid and H. Brenner$^*$
                      and B. Schöttker$^*$},
      title        = {{P}ain severity and analgesics use in the
                      community-dwelling older population: a drug utilization
                      study from {G}ermany.},
      journal      = {European journal of clinical pharmacology},
      volume       = {76},
      number       = {12},
      issn         = {1432-1041},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-01483},
      pages        = {1695-1707},
      year         = {2020},
      note         = {2020 Dec;76(12):1695-1707#EA:C070#LA:C070#},
      abstract     = {Chronic pain is common in the older population and a
                      significant public health concern. However, comprehensive
                      studies on analgesics use in this age group from Germany are
                      scarce. This study aims to give a comprehensive overview on
                      the use of the most common therapeutic groups of analgesics
                      in community-dwelling older adults from Germany.A
                      cross-sectional study was carried out using data from a
                      German cohort of 2038 community-dwelling adults aged
                      63-89 years. Descriptive statistics and logistic regression
                      models were applied to assess the utilization of analgesics
                      by age, sex, pain severity, pain duration, and locations.One
                      out of four study participants was suffering from
                      high-intensity or disabling pain. Approximately half of
                      those taking analgesics still reported to suffer from
                      high-intensity or disabling pain. Among analgesics users,
                      occasional non-steroidal anti-inflammatory drugs (NSAIDs)
                      use was the most frequent pain therapy (in $43.6\%$ of
                      users), followed by metamizole (dipyrone) use $(16.1\%),$
                      regular NSAIDs use $(12.9\%),$ strong opioids use
                      $(12.7\%),$ and weak opioids use $(12.0\%).$ In multivariate
                      logistic regression models, higher age, higher pain
                      severity, longer pain duration, abdominal pain, and back
                      pain were statistically significantly associated with
                      opioids use. Metamizole use was also statistically
                      significantly associated with higher pain severity but
                      inversely associated with pain duration.A significant number
                      of older German adults are affected by high-intensity and
                      disabling chronic pain despite receiving analgesics.
                      Long-term studies are needed to compare the effectiveness
                      and safety of different treatments for chronic pain in older
                      adults.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32648116},
      doi          = {10.1007/s00228-020-02954-5},
      url          = {https://inrepo02.dkfz.de/record/157213},
}