%0 Journal Article
%A Xu, Xing
%A Fallah, Mahdi
%A Tian, Yu
%A Mukama, Trasias
%A Sundquist, Kristina
%A Sundquist, Jan
%A Brenner, Hermann
%A Kharazmi, Elhamalsadat
%T Risk of invasive prostate cancer and prostate cancer death in relatives of patients with prostatic borderline or in situ neoplasia: A nationwide cohort study.
%J Cancer
%V 126
%N 19
%@ 0008-543X
%C New York, NY
%I Wiley-Liss
%M DKFZ-2020-01495
%P 4371-4378
%D 2020
%Z 2020 Oct 1;126(19):4371-4378#EA:C120#LA:C120#
%X The question of whether having a family history of prostatic borderline or in situ neoplasia (PBISN) is associated with an increased risk of invasive prostate cancer (PCa) or death from PCa remains unanswered. The objective of the current study was to provide an evidence-based risk estimation for the relatives of patients with PBISN.Nationwide Swedish family cancer data sets were used for the current study, including data regarding all residents of Sweden who were born after 1931 and their parents. Standardized incidence ratios (SIRs), standardized mortality ratios (SMRs), and lifetime cumulative risks of PCa were calculated for men with different constellations of family history. Family history was defined as a dynamic (time-dependent) variable considering changes during follow-up (1958-2015).Of the 6,343,727 men in the current study, a total of 238,961 developed invasive PCa and 5756 were diagnosed with PBISN during the follow-up. Men with 1 first-degree relative who was diagnosed with PBISN had a 70
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32697345
%R 10.1002/cncr.33096
%U https://inrepo02.dkfz.de/record/157225