% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Xu:157225,
      author       = {X. Xu$^*$ and M. Fallah$^*$ and Y. Tian$^*$ and T.
                      Mukama$^*$ and K. Sundquist and J. Sundquist and H.
                      Brenner$^*$ and E. Kharazmi$^*$},
      title        = {{R}isk of invasive prostate cancer and prostate cancer
                      death in relatives of patients with prostatic borderline or
                      in situ neoplasia: {A} nationwide cohort study.},
      journal      = {Cancer},
      volume       = {126},
      number       = {19},
      issn         = {0008-543X},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-01495},
      pages        = {4371-4378},
      year         = {2020},
      note         = {2020 Oct 1;126(19):4371-4378#EA:C120#LA:C120#},
      abstract     = {The question of whether having a family history of
                      prostatic borderline or in situ neoplasia (PBISN) is
                      associated with an increased risk of invasive prostate
                      cancer (PCa) or death from PCa remains unanswered. The
                      objective of the current study was to provide an
                      evidence-based risk estimation for the relatives of patients
                      with PBISN.Nationwide Swedish family cancer data sets were
                      used for the current study, including data regarding all
                      residents of Sweden who were born after 1931 and their
                      parents. Standardized incidence ratios (SIRs), standardized
                      mortality ratios (SMRs), and lifetime cumulative risks of
                      PCa were calculated for men with different constellations of
                      family history. Family history was defined as a dynamic
                      (time-dependent) variable considering changes during
                      follow-up (1958-2015).Of the 6,343,727 men in the current
                      study, a total of 238,961 developed invasive PCa and 5756
                      were diagnosed with PBISN during the follow-up. Men with 1
                      first-degree relative who was diagnosed with PBISN had a
                      $70\%$ increased risk of invasive PCa (SIR, 1.7; $95\%$
                      confidence interval, 1.5-1.9) and PCa death (SMR, 1.7;
                      $95\%$ confidence interval, 1.3-2.2) compared with men with
                      no family history of PBISN or invasive PCa. These were
                      rather close to estimates in men with 1 first-degree
                      relative diagnosed with invasive PCa (SIR, 2.1 and SMR,
                      1.8). A higher risk of PCa in family members was found among
                      patients with a family history of PBISN and/or PCa diagnosed
                      before age 60 years. The results in terms of cumulative risk
                      resembled this trend.A family history of PBISN appears to be
                      as important as a family history of invasive PCa with regard
                      to an increased risk of invasive PCa or PCa mortality. Such
                      a history should not be overlooked in PCa screening
                      recommendations or in future research regarding familial
                      PCa.},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32697345},
      doi          = {10.1002/cncr.33096},
      url          = {https://inrepo02.dkfz.de/record/157225},
}