%0 Journal Article
%A Zaidi, Syed H
%A Harrison, Tabitha A
%A Phipps, Amanda I
%A Steinfelder, Robert
%A Trinh, Quang M
%A Qu, Conghui
%A Banbury, Barbara L
%A Georgeson, Peter
%A Grasso, Catherine S
%A Giannakis, Marios
%A Adams, Jeremy B
%A Alwers, Elizabeth
%A Amitay, Efrat
%A Barfield, Richard T
%A Berndt, Sonja I
%A Borozan, Ivan
%A Brenner, Hermann
%A Brezina, Stefanie
%A Buchanan, Daniel D
%A Cao, Yin
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Connolly, Charles M
%A Drew, David A
%A Farris, Alton Brad
%A Figueiredo, Jane C
%A French, Amy J
%A Fuchs, Charles S
%A Garraway, Levi A
%A Gruber, Steve
%A Guinter, Mark A
%A Hamilton, Stanley R
%A Harlid, Sophia
%A Heisler, Lawrence E
%A Hidaka, Akihisa
%A Hopper, John L
%A Huang, Wen-Yi
%A Huyghe, Jeroen R
%A Jenkins, Mark A
%A Krzyzanowski, Paul M
%A Lemire, Mathieu
%A Lin, Yi
%A Luo, Xuemei
%A Mardis, Elaine R
%A McPherson, John D
%A Miller, Jessica K
%A Moreno, Victor
%A Mu, Xinmeng Jasmine
%A Nishihara, Reiko
%A Papadopoulos, Nickolas
%A Pasternack, Danielle
%A Quist, Michael J
%A Rafikova, Adilya
%A Reid, Emma E G
%A Shinbrot, Eve
%A Shirts, Brian H
%A Stein, Lincoln D
%A Teney, Cherie D
%A Timms, Lee
%A Um, Caroline Y
%A Van Guelpen, Bethany
%A Van Tassel, Megan
%A Wang, Xiaolong
%A Wheeler, David A
%A Yung, Christina K
%A Hsu, Li
%A Ogino, Shuji
%A Gsur, Andrea
%A Newcomb, Polly A
%A Gallinger, Steven
%A Hoffmeister, Michael
%A Campbell, Peter T
%A Thibodeau, Stephen N
%A Sun, Wei
%A Hudson, Thomas J
%A Peters, Ulrike
%T Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
%J Nature Communications
%V 11
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2020-01543
%P 3644
%D 2020
%X Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR = 0.42, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32686686
%2 pmc:PMC7371703
%R 10.1038/s41467-020-17386-z
%U https://inrepo02.dkfz.de/record/157300