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000157300 1001_ $$aZaidi, Syed H$$b0
000157300 245__ $$aLandscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
000157300 260__ $$a[London]$$bNature Publishing Group UK$$c2020
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000157300 520__ $$aColorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR = 0.42, 95% CI: 0.21-0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR = 1.53, 95% CI: 1.21-1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features.
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000157300 7001_ $$aPhipps, Amanda I$$b2
000157300 7001_ $$aSteinfelder, Robert$$b3
000157300 7001_ $$00000-0002-3602-2290$$aTrinh, Quang M$$b4
000157300 7001_ $$aQu, Conghui$$b5
000157300 7001_ $$aBanbury, Barbara L$$b6
000157300 7001_ $$00000-0002-5096-4735$$aGeorgeson, Peter$$b7
000157300 7001_ $$aGrasso, Catherine S$$b8
000157300 7001_ $$aGiannakis, Marios$$b9
000157300 7001_ $$aAdams, Jeremy B$$b10
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000157300 7001_ $$aBarfield, Richard T$$b13
000157300 7001_ $$aBerndt, Sonja I$$b14
000157300 7001_ $$00000-0002-3145-3550$$aBorozan, Ivan$$b15
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000157300 7001_ $$00000-0001-5238-6900$$aBrezina, Stefanie$$b17
000157300 7001_ $$00000-0003-2225-6675$$aBuchanan, Daniel D$$b18
000157300 7001_ $$aCao, Yin$$b19
000157300 7001_ $$00000-0001-7284-6767$$aChan, Andrew T$$b20
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000157300 7001_ $$aConnolly, Charles M$$b22
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000157300 7001_ $$00000-0001-5534-7763$$aFarris, Alton Brad$$b24
000157300 7001_ $$aFigueiredo, Jane C$$b25
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000157300 7001_ $$aFuchs, Charles S$$b27
000157300 7001_ $$aGarraway, Levi A$$b28
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000157300 7001_ $$aHamilton, Stanley R$$b31
000157300 7001_ $$00000-0001-8540-6891$$aHarlid, Sophia$$b32
000157300 7001_ $$aHeisler, Lawrence E$$b33
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000157300 7001_ $$aHopper, John L$$b35
000157300 7001_ $$aHuang, Wen-Yi$$b36
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000157300 7001_ $$aKrzyzanowski, Paul M$$b39
000157300 7001_ $$aLemire, Mathieu$$b40
000157300 7001_ $$aLin, Yi$$b41
000157300 7001_ $$aLuo, Xuemei$$b42
000157300 7001_ $$00000-0002-5892-1553$$aMardis, Elaine R$$b43
000157300 7001_ $$00000-0001-8049-9347$$aMcPherson, John D$$b44
000157300 7001_ $$aMiller, Jessica K$$b45
000157300 7001_ $$00000-0002-2818-5487$$aMoreno, Victor$$b46
000157300 7001_ $$aMu, Xinmeng Jasmine$$b47
000157300 7001_ $$aNishihara, Reiko$$b48
000157300 7001_ $$aPapadopoulos, Nickolas$$b49
000157300 7001_ $$aPasternack, Danielle$$b50
000157300 7001_ $$aQuist, Michael J$$b51
000157300 7001_ $$aRafikova, Adilya$$b52
000157300 7001_ $$aReid, Emma E G$$b53
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000157300 7001_ $$00000-0002-7188-6764$$aShirts, Brian H$$b55
000157300 7001_ $$aStein, Lincoln D$$b56
000157300 7001_ $$aTeney, Cherie D$$b57
000157300 7001_ $$aTimms, Lee$$b58
000157300 7001_ $$00000-0001-5449-6230$$aUm, Caroline Y$$b59
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000157300 7001_ $$aVan Tassel, Megan$$b61
000157300 7001_ $$aWang, Xiaolong$$b62
000157300 7001_ $$00000-0002-9056-6299$$aWheeler, David A$$b63
000157300 7001_ $$00000-0003-2958-150X$$aYung, Christina K$$b64
000157300 7001_ $$aHsu, Li$$b65
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