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@ARTICLE{Zaidi:157300,
      author       = {S. H. Zaidi and T. A. Harrison and A. I. Phipps and R.
                      Steinfelder and Q. M. Trinh and C. Qu and B. L. Banbury and
                      P. Georgeson and C. S. Grasso and M. Giannakis and J. B.
                      Adams and E. Alwers$^*$ and E. Amitay$^*$ and R. T. Barfield
                      and S. I. Berndt and I. Borozan and H. Brenner$^*$ and S.
                      Brezina and D. D. Buchanan and Y. Cao and A. T. Chan and J.
                      Chang-Claude$^*$ and C. M. Connolly and D. A. Drew and A. B.
                      Farris and J. C. Figueiredo and A. J. French and C. S. Fuchs
                      and L. A. Garraway and S. Gruber and M. A. Guinter and S. R.
                      Hamilton and S. Harlid and L. E. Heisler and A. Hidaka and
                      J. L. Hopper and W.-Y. Huang and J. R. Huyghe and M. A.
                      Jenkins and P. M. Krzyzanowski and M. Lemire and Y. Lin and
                      X. Luo and E. R. Mardis and J. D. McPherson and J. K. Miller
                      and V. Moreno and X. J. Mu and R. Nishihara and N.
                      Papadopoulos and D. Pasternack and M. J. Quist and A.
                      Rafikova and E. E. G. Reid and E. Shinbrot and B. H. Shirts
                      and L. D. Stein and C. D. Teney and L. Timms and C. Y. Um
                      and B. Van Guelpen and M. Van Tassel and X. Wang and D. A.
                      Wheeler and C. K. Yung and L. Hsu and S. Ogino and A. Gsur
                      and P. A. Newcomb and S. Gallinger and M. Hoffmeister$^*$
                      and P. T. Campbell and S. N. Thibodeau and W. Sun and T. J.
                      Hudson and U. Peters},
      title        = {{L}andscape of somatic single nucleotide variants and
                      indels in colorectal cancer and impact on survival.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-01543},
      pages        = {3644},
      year         = {2020},
      abstract     = {Colorectal cancer (CRC) is a biologically heterogeneous
                      disease. To characterize its mutational profile, we conduct
                      targeted sequencing of 205 genes for 2,105 CRC cases with
                      survival data. Our data shows several findings in addition
                      to enhancing the existing knowledge of CRC. We identify
                      PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional
                      genes significantly mutated in CRC. We find that among
                      hypermutated tumors, an increased mutation burden is
                      associated with improved CRC-specific survival
                      (HR = 0.42, $95\%$ CI: 0.21-0.82). Mutations in TP53 are
                      associated with poorer CRC-specific survival, which is most
                      pronounced in cases carrying TP53 mutations with predicted
                      $0\%$ transcriptional activity (HR = 1.53, $95\%$ CI:
                      1.21-1.94). Furthermore, we observe differences in
                      mutational frequency of several genes and pathways by tumor
                      location, stage, and sex. Overall, this large study provides
                      deep insights into somatic mutations in CRC, and their
                      potential relationships with survival and tumor features.},
      cin          = {C070 / C120 / HD01 / C020},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32686686},
      pmc          = {pmc:PMC7371703},
      doi          = {10.1038/s41467-020-17386-z},
      url          = {https://inrepo02.dkfz.de/record/157300},
}