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@ARTICLE{Thomsen:157349,
      author       = {H. Thomsen and X. Li and K. Sundquist and J. Sundquist and
                      A. Försti$^*$ and K. Hemminki$^*$},
      title        = {{F}amilial risks between {G}raves disease and {H}ashimoto
                      thyroiditis and other autoimmune diseases in the population
                      of {S}weden.},
      journal      = {Journal of translational autoimmunity},
      volume       = {3},
      issn         = {2589-9090},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01578},
      pages        = {100058},
      year         = {2020},
      note         = {Journal of Translational Autoimmunity (Journal of
                      Translational Autoimmunity) = 2589-9090 (import from
                      CrossRef, PubMed, )#EA:C050#LA:C050#},
      abstract     = {Genetic and family studies have indicated that Graves
                      disease and Hashimoto thyroiditis have a heritable component
                      which appears to be shared to some extend also with some
                      other autoimmune diseases (AIDs). In the present nation-wide
                      study we describe familial risk for Graves disease and
                      Hashimoto thyroiditis identified from the Swedish Hospital
                      Discharge Register (years 1964 through 2012) and the
                      Outpatient Register (2001 through 2012). Family
                      relationships were obtained from the Multigeneration
                      Register and cancers from the Cancer Registry. Familial
                      standardized incidence ratios (SIRs) were calculated for
                      29,005 offspring with Graves disease and for 25,607
                      offspring with Hashimoto thyroiditis depending on any of 43
                      AIDs in parents or siblings. The concordant familial risks
                      for Graves disease and Hashimoto thyroiditis were 3.85 and
                      4.75, higher for men than for women. The familial risks were
                      very high (11.35, Graves and 22.06, Hashimoto) when both a
                      parent and a sibling were affected. Spousal familial risks
                      were higher for Hashimoto thyroiditis (1.98/1.93) than for
                      Graves disease (1.48/1.50). For Graves disease, 24
                      discordant AIDs showed a significant association; for
                      Hashimoto thyroiditis, 20 discordant associations were
                      significant. All significant discordant associations were
                      positive for the two thyroid AIDs, with the exception of
                      Hashimoto thyroiditis with Reiter disease. Overall 8
                      associations were significant only for Graves disease and 6
                      Hashimoto thyroiditis. The overall high concordant familial
                      risks for Graves disease and Hashimoto thyroiditis suggest a
                      strong genetic contribution to the familial risk.
                      Significant familial associations among more than half of
                      the 43 AIDs attest to the extensive polyautoimmunity among
                      thyroid AIDs.},
      cin          = {C050 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32743538},
      pmc          = {pmc:PMC7388361},
      doi          = {10.1016/j.jtauto.2020.100058},
      url          = {https://inrepo02.dkfz.de/record/157349},
}