% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Scherer:157411,
      author       = {D. Scherer$^*$ and H. Deutelmoser$^*$ and Y. Balavarca$^*$
                      and R. Toth$^*$ and N. Habermann$^*$ and K. Buck$^*$ and E.
                      J. Kap$^*$ and A. Botma$^*$ and P. Seibold$^*$ and L.
                      Jansen$^*$ and J. Lorenzo Bermejo and K. Weigl$^*$ and A.
                      Benner$^*$ and M. Hoffmeister$^*$ and A. Ulrich and H.
                      Brenner$^*$ and B. Burwinkel$^*$ and J. Chang-Claude$^*$ and
                      C. M. Ulrich},
      title        = {{P}olymorphisms in the {A}ngiogenesis-{R}elated {G}enes
                      {EFNB}2, {MMP}2 and {JAG}1 {A}re {A}ssociated with
                      {S}urvival of {C}olorectal {C}ancer {P}atients.},
      journal      = {International journal of molecular sciences},
      volume       = {21},
      number       = {15},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2020-01606},
      pages        = {5395},
      year         = {2020},
      note         = {#EA:C120#},
      abstract     = {An individual's inherited genetic variation may contribute
                      to the 'angiogenic switch', which is essential for blood
                      supply and tumor growth of microscopic and macroscopic
                      tumors. Polymorphisms in angiogenesis-related genes
                      potentially predispose to colorectal cancer (CRC) or affect
                      the survival of CRC patients. We investigated the
                      association of 392 single nucleotide polymorphisms (SNPs) in
                      33 angiogenesis-related genes with CRC risk and survival of
                      CRC patients in 1754 CRC cases and 1781 healthy controls
                      within DACHS (Darmkrebs: Chancen der Verhütung durch
                      Screening), a German population-based case-control study.
                      Odds ratios and $95\%$ confidence intervals (CI) were
                      estimated from unconditional logistic regression to test for
                      genetic associations with CRC risk. The Cox proportional
                      hazard model was used to estimate hazard ratios (HR) and
                      $95\%$ CIs for survival. Multiple testing was adjusted for
                      by a false discovery rate. No variant was associated with
                      CRC risk. Variants in EFNB2, MMP2 and JAG1 were
                      significantly associated with overall survival. The
                      association of the EFNB2 tagging SNP rs9520090 (p < 0.0001)
                      was confirmed in two validation datasets (p-values: 0.01 and
                      0.05). The associations of the tagging SNPs rs6040062 in
                      JAG1 (p-value 0.0003) and rs2241145 in MMP2 (p-value 0.0005)
                      showed the same direction of association with overall
                      survival in the first and second validation sets,
                      respectively, although they did not reach significance
                      (p-values: 0.09 and 0.25, respectively). EFNB2, MMP2 and
                      JAG1 are known for their functional role in angiogenesis and
                      the present study points to novel evidence for the impact of
                      angiogenesis-related genetic variants on the CRC outcome.},
      cin          = {C120 / B370 / C020 / C070 / C060 / HD01 / C080},
      ddc          = {540},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)B370-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C080-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32751332},
      doi          = {10.3390/ijms21155395},
      url          = {https://inrepo02.dkfz.de/record/157411},
}