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000157425 1001_ $$aWu, Lang$$b0
000157425 245__ $$aAn integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
000157425 260__ $$a[London]$$bNature Publishing Group UK$$c2020
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000157425 520__ $$aIt remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes.
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000157425 7001_ $$aYang, Yaohua$$b1
000157425 7001_ $$aGuo, Xingyi$$b2
000157425 7001_ $$aShu, Xiao-Ou$$b3
000157425 7001_ $$aCai, Qiuyin$$b4
000157425 7001_ $$aShu, Xiang$$b5
000157425 7001_ $$00000-0003-2129-168X$$aLi, Bingshan$$b6
000157425 7001_ $$aTao, Ran$$b7
000157425 7001_ $$00000-0002-8400-1785$$aWu, Chong$$b8
000157425 7001_ $$00000-0001-9703-0422$$aNikas, Jason B$$b9
000157425 7001_ $$aSun, Yanfa$$b10
000157425 7001_ $$aZhu, Jingjing$$b11
000157425 7001_ $$00000-0001-6967-1708$$aRoobol, Monique J$$b12
000157425 7001_ $$00000-0003-4946-9099$$aGiles, Graham G$$b13
000157425 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b14$$udkfz
000157425 7001_ $$aJohn, Esther M$$b15
000157425 7001_ $$aClements, Judith$$b16
000157425 7001_ $$aGrindedal, Eli Marie$$b17
000157425 7001_ $$aPark, Jong Y$$b18
000157425 7001_ $$aStanford, Janet L$$b19
000157425 7001_ $$aKote-Jarai, Zsofia$$b20
000157425 7001_ $$aHaiman, Christopher A$$b21
000157425 7001_ $$00000-0002-3698-6241$$aEeles, Rosalind A$$b22
000157425 7001_ $$00000-0003-1226-070X$$aZheng, Wei$$b23
000157425 7001_ $$aLong, Jirong$$b24
000157425 7001_ $$aconsortium, PRACTICAL$$b25$$eCollaboration Author
000157425 7001_ $$aConsortium, CRUK$$b26$$eCollaboration Author
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000157425 7001_ $$aEeles, Rosalind A$$b30
000157425 7001_ $$aHenderson, Brian E$$b31
000157425 7001_ $$aHaiman, Christopher A$$b32
000157425 7001_ $$aKote-Jarai, Zsofia$$b33
000157425 7001_ $$aSchumacher, Fredrick R$$b34
000157425 7001_ $$aEaston, Douglas$$b35
000157425 7001_ $$aBenlloch, Sara$$b36
000157425 7001_ $$aOlama, Ali Amin Al$$b37
000157425 7001_ $$aMuir, Kenneth$$b38
000157425 7001_ $$aBerndt, Sonja I$$b39
000157425 7001_ $$aConti, David V$$b40
000157425 7001_ $$aWiklund, Fredrik$$b41
000157425 7001_ $$aChanock, Stephen$$b42
000157425 7001_ $$aGapstur, Susan M$$b43
000157425 7001_ $$aStevens, Victoria L$$b44
000157425 7001_ $$aTangen, Catherine M$$b45
000157425 7001_ $$aBatra, Jyotsna$$b46
000157425 7001_ $$aClements, Judith$$b47
000157425 7001_ $$aGronberg, Henrik$$b48
000157425 7001_ $$aPashayan, Nora$$b49
000157425 7001_ $$aSchleutker, Johanna$$b50
000157425 7001_ $$aAlbanes, Demetrius$$b51
000157425 7001_ $$aWeinstein, Stephanie$$b52
000157425 7001_ $$aWolk, Alicja$$b53
000157425 7001_ $$aWest, Catharine$$b54
000157425 7001_ $$aMucci, Lorelei$$b55
000157425 7001_ $$aCancel-Tassin, Géraldine$$b56
000157425 7001_ $$aKoutros, Stella$$b57
000157425 7001_ $$aSorensen, Karina Dalsgaard$$b58
000157425 7001_ $$aGrindedal, Eli Marie$$b59
000157425 7001_ $$aNeal, David E$$b60
000157425 7001_ $$aHamdy, Freddie C$$b61
000157425 7001_ $$aDonovan, Jenny L$$b62
000157425 7001_ $$aTravis, Ruth C$$b63
000157425 7001_ $$aHamilton, Robert J$$b64
000157425 7001_ $$aIngles, Sue Ann$$b65
000157425 7001_ $$aRosenstein, Barry S$$b66
000157425 7001_ $$aLu, Yong-Jie$$b67
000157425 7001_ $$aGiles, Graham G$$b68
000157425 7001_ $$aKibel, Adam S$$b69
000157425 7001_ $$aVega, Ana$$b70
000157425 7001_ $$aKogevinas, Manolis$$b71
000157425 7001_ $$aPenney, Kathryn L$$b72
000157425 7001_ $$aPark, Jong Y$$b73
000157425 7001_ $$aStanford, Janet L$$b74
000157425 7001_ $$aCybulski, Cezary$$b75
000157425 7001_ $$aNordestgaard, Børge G$$b76
000157425 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b77$$udkfz
000157425 7001_ $$aMaier, Christiane$$b78
000157425 7001_ $$aKim, Jeri$$b79
000157425 7001_ $$aJohn, Esther M$$b80
000157425 7001_ $$aTeixeira, Manuel R$$b81
000157425 7001_ $$aNeuhausen, Susan L$$b82
000157425 7001_ $$aDe Ruyck, Kim$$b83
000157425 7001_ $$aRazack, Azad$$b84
000157425 7001_ $$aNewcomb, Lisa F$$b85
000157425 7001_ $$aGamulin, Marija$$b86
000157425 7001_ $$aKaneva, Radka$$b87
000157425 7001_ $$aUsmani, Nawaid$$b88
000157425 7001_ $$aClaessens, Frank$$b89
000157425 7001_ $$aTownsend, Paul A$$b90
000157425 7001_ $$aDominguez, Manuela Gago$$b91
000157425 7001_ $$aRoobol, Monique J$$b92
000157425 7001_ $$aMenegaux, Florence$$b93
000157425 7001_ $$aKhaw, Kay-Tee$$b94
000157425 7001_ $$aCannon-Albright, Lisa$$b95
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000157425 7001_ $$aHenderson, Brian E$$b109
000157425 7001_ $$aHaiman, Christopher A$$b110
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000157425 7001_ $$aBerndt, Sonja I$$b112
000157425 7001_ $$aChanock, Stephen$$b113
000157425 7001_ $$aGapstur, Susan M$$b114
000157425 7001_ $$aStevens, Victoria L$$b115
000157425 7001_ $$aAlbanes, Demetrius$$b116
000157425 7001_ $$aWeinstein, Stephanie$$b117
000157425 7001_ $$aMucci, Lorelei$$b118
000157425 7001_ $$aKoutros, Stella$$b119
000157425 7001_ $$aTravis, Ruth C$$b120
000157425 7001_ $$aPenney, Kathryn L$$b121
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000157425 7001_ $$aChanock, Stephen$$b127
000157425 7001_ $$aAlbanes, Demetrius$$b128
000157425 7001_ $$aWeinstein, Stephanie$$b129
000157425 7001_ $$aKoutros, Stella$$b130
000157425 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-17673-9$$gVol. 11, no. 1, p. 3905$$n1$$p3905$$tNature Communications$$v11$$x2041-1723$$y2020
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