guest ::
| Home > Publications database > An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk. > print |
| Home > Publications database > An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk. > print |
| 001 | 157425 | ||
| 005 | 20240229123138.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-020-17673-9 |2 doi |
| 024 | 7 | _ | |a pmid:32764609 |2 pmid |
| 024 | 7 | _ | |a altmetric:87826569 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2020-01620 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Wu, Lang |b 0 |
| 245 | _ | _ | |a An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk. |
| 260 | _ | _ | |a [London] |c 2020 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1597134766_28060 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Yang, Yaohua |b 1 |
| 700 | 1 | _ | |a Guo, Xingyi |b 2 |
| 700 | 1 | _ | |a Shu, Xiao-Ou |b 3 |
| 700 | 1 | _ | |a Cai, Qiuyin |b 4 |
| 700 | 1 | _ | |a Shu, Xiang |b 5 |
| 700 | 1 | _ | |a Li, Bingshan |0 0000-0003-2129-168X |b 6 |
| 700 | 1 | _ | |a Tao, Ran |b 7 |
| 700 | 1 | _ | |a Wu, Chong |0 0000-0002-8400-1785 |b 8 |
| 700 | 1 | _ | |a Nikas, Jason B |0 0000-0001-9703-0422 |b 9 |
| 700 | 1 | _ | |a Sun, Yanfa |b 10 |
| 700 | 1 | _ | |a Zhu, Jingjing |b 11 |
| 700 | 1 | _ | |a Roobol, Monique J |0 0000-0001-6967-1708 |b 12 |
| 700 | 1 | _ | |a Giles, Graham G |0 0000-0003-4946-9099 |b 13 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 14 |u dkfz |
| 700 | 1 | _ | |a John, Esther M |b 15 |
| 700 | 1 | _ | |a Clements, Judith |b 16 |
| 700 | 1 | _ | |a Grindedal, Eli Marie |b 17 |
| 700 | 1 | _ | |a Park, Jong Y |b 18 |
| 700 | 1 | _ | |a Stanford, Janet L |b 19 |
| 700 | 1 | _ | |a Kote-Jarai, Zsofia |b 20 |
| 700 | 1 | _ | |a Haiman, Christopher A |b 21 |
| 700 | 1 | _ | |a Eeles, Rosalind A |0 0000-0002-3698-6241 |b 22 |
| 700 | 1 | _ | |a Zheng, Wei |0 0000-0003-1226-070X |b 23 |
| 700 | 1 | _ | |a Long, Jirong |b 24 |
| 700 | 1 | _ | |a consortium, PRACTICAL |b 25 |e Collaboration Author |
| 700 | 1 | _ | |a Consortium, CRUK |b 26 |e Collaboration Author |
| 700 | 1 | _ | |a Consortium, BPC3 |b 27 |e Collaboration Author |
| 700 | 1 | _ | |a Consortium, CAPS |b 28 |e Collaboration Author |
| 700 | 1 | _ | |a Consortium, PEGASUS |b 29 |e Collaboration Author |
| 700 | 1 | _ | |a Eeles, Rosalind A |b 30 |
| 700 | 1 | _ | |a Henderson, Brian E |b 31 |
| 700 | 1 | _ | |a Haiman, Christopher A |b 32 |
| 700 | 1 | _ | |a Kote-Jarai, Zsofia |b 33 |
| 700 | 1 | _ | |a Schumacher, Fredrick R |b 34 |
| 700 | 1 | _ | |a Easton, Douglas |b 35 |
| 700 | 1 | _ | |a Benlloch, Sara |b 36 |
| 700 | 1 | _ | |a Olama, Ali Amin Al |b 37 |
| 700 | 1 | _ | |a Muir, Kenneth |b 38 |
| 700 | 1 | _ | |a Berndt, Sonja I |b 39 |
| 700 | 1 | _ | |a Conti, David V |b 40 |
| 700 | 1 | _ | |a Wiklund, Fredrik |b 41 |
| 700 | 1 | _ | |a Chanock, Stephen |b 42 |
| 700 | 1 | _ | |a Gapstur, Susan M |b 43 |
| 700 | 1 | _ | |a Stevens, Victoria L |b 44 |
| 700 | 1 | _ | |a Tangen, Catherine M |b 45 |
| 700 | 1 | _ | |a Batra, Jyotsna |b 46 |
| 700 | 1 | _ | |a Clements, Judith |b 47 |
| 700 | 1 | _ | |a Gronberg, Henrik |b 48 |
| 700 | 1 | _ | |a Pashayan, Nora |b 49 |
| 700 | 1 | _ | |a Schleutker, Johanna |b 50 |
| 700 | 1 | _ | |a Albanes, Demetrius |b 51 |
| 700 | 1 | _ | |a Weinstein, Stephanie |b 52 |
| 700 | 1 | _ | |a Wolk, Alicja |b 53 |
| 700 | 1 | _ | |a West, Catharine |b 54 |
| 700 | 1 | _ | |a Mucci, Lorelei |b 55 |
| 700 | 1 | _ | |a Cancel-Tassin, Géraldine |b 56 |
| 700 | 1 | _ | |a Koutros, Stella |b 57 |
| 700 | 1 | _ | |a Sorensen, Karina Dalsgaard |b 58 |
| 700 | 1 | _ | |a Grindedal, Eli Marie |b 59 |
| 700 | 1 | _ | |a Neal, David E |b 60 |
| 700 | 1 | _ | |a Hamdy, Freddie C |b 61 |
| 700 | 1 | _ | |a Donovan, Jenny L |b 62 |
| 700 | 1 | _ | |a Travis, Ruth C |b 63 |
| 700 | 1 | _ | |a Hamilton, Robert J |b 64 |
| 700 | 1 | _ | |a Ingles, Sue Ann |b 65 |
| 700 | 1 | _ | |a Rosenstein, Barry S |b 66 |
| 700 | 1 | _ | |a Lu, Yong-Jie |b 67 |
| 700 | 1 | _ | |a Giles, Graham G |b 68 |
| 700 | 1 | _ | |a Kibel, Adam S |b 69 |
| 700 | 1 | _ | |a Vega, Ana |b 70 |
| 700 | 1 | _ | |a Kogevinas, Manolis |b 71 |
| 700 | 1 | _ | |a Penney, Kathryn L |b 72 |
| 700 | 1 | _ | |a Park, Jong Y |b 73 |
| 700 | 1 | _ | |a Stanford, Janet L |b 74 |
| 700 | 1 | _ | |a Cybulski, Cezary |b 75 |
| 700 | 1 | _ | |a Nordestgaard, Børge G |b 76 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 77 |u dkfz |
| 700 | 1 | _ | |a Maier, Christiane |b 78 |
| 700 | 1 | _ | |a Kim, Jeri |b 79 |
| 700 | 1 | _ | |a John, Esther M |b 80 |
| 700 | 1 | _ | |a Teixeira, Manuel R |b 81 |
| 700 | 1 | _ | |a Neuhausen, Susan L |b 82 |
| 700 | 1 | _ | |a De Ruyck, Kim |b 83 |
| 700 | 1 | _ | |a Razack, Azad |b 84 |
| 700 | 1 | _ | |a Newcomb, Lisa F |b 85 |
| 700 | 1 | _ | |a Gamulin, Marija |b 86 |
| 700 | 1 | _ | |a Kaneva, Radka |b 87 |
| 700 | 1 | _ | |a Usmani, Nawaid |b 88 |
| 700 | 1 | _ | |a Claessens, Frank |b 89 |
| 700 | 1 | _ | |a Townsend, Paul A |b 90 |
| 700 | 1 | _ | |a Dominguez, Manuela Gago |b 91 |
| 700 | 1 | _ | |a Roobol, Monique J |b 92 |
| 700 | 1 | _ | |a Menegaux, Florence |b 93 |
| 700 | 1 | _ | |a Khaw, Kay-Tee |b 94 |
| 700 | 1 | _ | |a Cannon-Albright, Lisa |b 95 |
| 700 | 1 | _ | |a Pandha, Hardev |b 96 |
| 700 | 1 | _ | |a Thibodeau, Stephen N |b 97 |
| 700 | 1 | _ | |a Hunter, David J |b 98 |
| 700 | 1 | _ | |a Blot, William J |b 99 |
| 700 | 1 | _ | |a Riboli, Elio |b 100 |
| 700 | 1 | _ | |a Eeles, Rosalind A |b 101 |
| 700 | 1 | _ | |a Kote-Jarai, Zsofia |b 102 |
| 700 | 1 | _ | |a West, Catharine |b 103 |
| 700 | 1 | _ | |a Neal, David E |b 104 |
| 700 | 1 | _ | |a Hamdy, Freddie C |b 105 |
| 700 | 1 | _ | |a Donovan, Jenny L |b 106 |
| 700 | 1 | _ | |a Travis, Ruth C |b 107 |
| 700 | 1 | _ | |a Riboli, Elio |b 108 |
| 700 | 1 | _ | |a Henderson, Brian E |b 109 |
| 700 | 1 | _ | |a Haiman, Christopher A |b 110 |
| 700 | 1 | _ | |a Schumacher, Fredrick R |b 111 |
| 700 | 1 | _ | |a Berndt, Sonja I |b 112 |
| 700 | 1 | _ | |a Chanock, Stephen |b 113 |
| 700 | 1 | _ | |a Gapstur, Susan M |b 114 |
| 700 | 1 | _ | |a Stevens, Victoria L |b 115 |
| 700 | 1 | _ | |a Albanes, Demetrius |b 116 |
| 700 | 1 | _ | |a Weinstein, Stephanie |b 117 |
| 700 | 1 | _ | |a Mucci, Lorelei |b 118 |
| 700 | 1 | _ | |a Koutros, Stella |b 119 |
| 700 | 1 | _ | |a Travis, Ruth C |b 120 |
| 700 | 1 | _ | |a Penney, Kathryn L |b 121 |
| 700 | 1 | _ | |a Hunter, David J |b 122 |
| 700 | 1 | _ | |a Riboli, Elio |b 123 |
| 700 | 1 | _ | |a Wiklund, Fredrik |b 124 |
| 700 | 1 | _ | |a Gronberg, Henrik |b 125 |
| 700 | 1 | _ | |a Berndt, Sonja I |b 126 |
| 700 | 1 | _ | |a Chanock, Stephen |b 127 |
| 700 | 1 | _ | |a Albanes, Demetrius |b 128 |
| 700 | 1 | _ | |a Weinstein, Stephanie |b 129 |
| 700 | 1 | _ | |a Koutros, Stella |b 130 |
| 773 | _ | _ | |a 10.1038/s41467-020-17673-9 |g Vol. 11, no. 1, p. 3905 |0 PERI:(DE-600)2553671-0 |n 1 |p 3905 |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:157425 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 77 |6 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-313 |2 G:(DE-HGF)POF3-300 |v Cancer risk factors and prevention |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2020 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT COMMUN : 2018 |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2020-01-16 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Peer review |d 2020-01-16 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2020-01-16 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2020-01-16 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2020-01-16 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2020-01-16 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b NAT COMMUN : 2018 |d 2020-01-16 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |f 2020-01-16 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2020-01-16 |
| 920 | 1 | _ | |0 I:(DE-He78)C070-20160331 |k C070 |l C070 Klinische Epidemiologie und Alternf. |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)C120-20160331 |k C120 |l Präventive Onkologie |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 2 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)C070-20160331 |
| 980 | _ | _ | |a I:(DE-He78)C120-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|