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@ARTICLE{Raut:157469,
      author       = {J. Raut$^*$ and Z. Guan$^*$ and P. Schrotz-King$^*$ and H.
                      Brenner$^*$},
      title        = {{F}ecal {DNA} methylation markers for detecting stages of
                      colorectal cancer and its precursors: a systematic review.},
      journal      = {Clinical epigenetics},
      volume       = {12},
      number       = {1},
      issn         = {1868-7083},
      address      = {[S.l.]},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2020-01648},
      pages        = {122},
      year         = {2020},
      note         = {#EA:C120#LA:C070},
      abstract     = {DNA methylation biomarkers in stool may have applications
                      in early colorectal cancer (CRC) detection; however, their
                      association with stages of CRC carcinogenesis or their
                      performance in detecting various stages is unclear. We aimed
                      to systematically review the evidence for DNA methylation
                      markers in stool for risk stratification or detection of
                      specific CRC stages, as well as precursors of CRC.We
                      conducted a systematic search in line with the Preferred
                      Reporting Items for Systematic Reviews and Meta-Analyses
                      guidelines. We searched PubMed and ISI Web of Knowledge to
                      identify relevant studies published until 14th January 2020.
                      Two reviewers independently extracted data on study
                      population characteristics, candidate genes, methylation
                      measurement methods, odds ratios (ORs), overall and
                      stage-specific sensitivities, specificities, areas under the
                      receiver operating characteristics curve, and p-values for
                      statistical significance for OR and for association of
                      methylation levels with stage.Twenty-seven studies that
                      reported stage-specific associations or performances of
                      fecal DNA methylation markers for detecting colorectal
                      neoplasms were identified. All studies used
                      methylation-specific polymerase chain reaction for assessing
                      methylation levels in the promoter or exon 1 regions of
                      targeted genes. However, most studies were underpowered and
                      limited by their case-control design. Furthermore, the
                      stage-specific associations or sensitivities were validated
                      for two markers (hypermethylation of GATA4 and VIM)
                      only.Methylation markers in stool may be useful for
                      detection of CRC precursors or CRC staging, but promising
                      candidate markers need to be validated in longitudinal
                      studies on large screening populations, performing
                      epigenome-wide analyses. Identification of stage-specific
                      DNA methylation biomarkers in stool could boost current
                      strategies towards early detection and enable different
                      approaches to precision medicine for CRC.},
      subtyp        = {Review Article},
      cin          = {C120 / C070 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32778176},
      doi          = {10.1186/s13148-020-00904-7},
      url          = {https://inrepo02.dkfz.de/record/157469},
}